70442

1-Naphthol

≥98.0% (GC)

• Synonym(s): α-Naphthol, 1-Hydroxynaphthalene
• Linear Formula: C₁₀H₇OH
• CAS Number: 90-15-3
• Molecular Weight: 144.17
• Beilstein/REAXYS Number: 1817321
• EC Number: 201-969-4
• MDL number: MFCD00003930
• UNSPSC Code: 12352100
• PubChem Substance ID: 57652248

Properties

• vapor density: 4.5 (120 °C, vs air)
• vapor pressure: 1 mmHg ( 94 °C)
• assay: ≥98.0% (GC)
• autoignition temp.: 1007 °F
• expl. lim.: 5 %
• bp: 278-280 °C (lit.)
• mp: 94-96 °C (lit.); 94-96 °C
• SMILES string: Oc1cccc2ccccc12
• InChI: 1S/C10H8O/c11-10-7-3-5-8-4-1-2-6-9(8)10/h1-7,11H
• InChI key: KJCVRFUGPWSIIH-UHFFFAOYSA-N
• Gene Information: human ... CYP1A2(1544)

Description

General description

1-Naphthol is the hydroxyl derivative of naphthalene. It forms hydrogen bonded complexes with H₂O, CH₃OH, NH₃ and ND₃ in gas phase. Hydrogen-bond dissociation energy of these complexes has been evaluated. Its sorption by biochars (obtained from orange peels, having pyrolytic temperatures in the range of 150-700 °C and designated as OP150-OP700) has been studied. It has been identified as an impurity in the active pharmaceutical ingredient (API) of duloxetine hydrochloride.

Application

1-Naphthol (Naphthalen-1-ol) may be used as a standard for the NMR, FT-IR and mass spectrometric characterization of impurities present in the Duloxetine Hydrochloride active pharmaceutical ingredient (API).

Safety Information

• pictograms: GHS06,GHS08,GHS05,GHS09
• signalword: Danger
• hcodes: H302,H311,H315,H317,H318,H335,H371,H410
• pcodes: P273 - P280 - P301 + P312 - P302 + P352 + P312 - P305 + P351 + P338 - P308 + P311
• Hazard Classifications: Acute Tox. 3 Dermal - Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 3 - Eye Dam. 1 - Skin Irrit. 2 - Skin Sens. 1A - STOT SE 2 Oral - STOT SE 3
• target_organs: Kidney, Respiratory system
• Storage Class: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• wgk_germany: WGK 1
• flash_point_f: 257.0 °F - closed cup
• flash_point_c: 125 °C - closed cup
• ppe: dust mask type N95 (US), Eyeshields, Faceshields, Gloves