49432
Pyridine-3-sulfonyl chloride
for HPLC derivatization, LiChropur™, ≥98.0% (GC)
Synonym(s):
3-Pyridinesulfonyl chloride, 3-Pyridylsulfonyl chloride
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About This Item
Empirical Formula (Hill Notation):
C5H4ClNO2S
Molecular Weight:
177.61
Beilstein/REAXYS Number:
120820
MDL number:
UNSPSC Code:
12352200
Recommended Products
grade
derivatization grade ((HPLC))
for HPLC derivatization
Quality Level
assay
≥98.0% (GC)
97.0-103.0% (AT)
quality
LiChropur™
technique(s)
HPLC: suitable
storage temp.
2-8°C
SMILES string
O=S(C1=CC=CN=C1)(Cl)=O
General description
Pyridine-3-sulfonyl chloride belongs to the class of substituted sulfonyl chlorides, which can be used as derivatization agents owing to their high proton affinity.[1]
Application
Pyridine-3-sulfonyl chloride may be used as a derivatization agent to enhance the sensitivity of metabolites formed during the incubation of cytochrome P450 isoforms in aqueous medium,[2] steroidal estrogens in biological samples,[1] and bisphenols in beverages[3] for their subsequent determination by high performance liquid chromatography coupled to tandem mass spectrometry (HPLC-MS/MS).
Legal Information
LiChropur is a trademark of Merck KGaA, Darmstadt, Germany
signalword
Danger
hcodes
Hazard Classifications
Eye Dam. 1 - Skin Corr. 1B - STOT SE 3
target_organs
Respiratory system
Storage Class
8A - Combustible corrosive hazardous materials
wgk_germany
WGK 3
flash_point_f
No data available
flash_point_c
No data available
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In vitro cytochrome P450 activity: development and validation of a sensitive high performance liquid chromatography-tandem mass spectrometry method for the quantification of six probe metabolites after derivatization with pyridine-3-sulfonyl chloride in an aqueous environment
De Bock L, et al.
Journal of Chromatography A, 1218(6), 793-801 (2011)
Determination of bisphenols in beverages by mixed-mode solid-phase extraction and liquid chromatography coupled to tandem mass spectrometry
Regueiro J and Wenzl T
Journal of Chromatography A, 1422(1), 230-238 (2015)
Li Xu et al.
Analytical biochemistry, 375(1), 105-114 (2007-12-29)
Sulfonyl chlorides substituted with functional groups having high proton affinity can serve as derivatization reagents to enhance the sensitivity for steroidal estrogens in liquid chromatography electrospray ionization tandem mass spectrometry (LC-ESI-MS/MS). The most commonly used reagent for derivatization of estrogens
Chemical derivatization to enhance ionization of anabolic steroids in LC-MS for doping-control analysis.
Athanasiadou, I., et al.
Trends in Analytical Chemistry, 42, 137-156 (2013)
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