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49431

Sigma-Aldrich

Dichloroacetic acid solution

suitable for DNA synthesis, 3% in methylene chloride

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About This Item

Empirical Formula (Hill Notation):
C2H2Cl2O2
CAS Number:
79-43-6
Molecular Weight:
128.94
Beilstein/REAXYS Number:
1098596
MDL number:
MFCD00004223
UNSPSC Code:
12161700
PubChem Substance ID:
329757449

concentration

3% in methylene chloride

technique(s)

DNA synthesis: suitable

impurities

≤0.01% water

density

1.335 g/mL at 20 °C

SMILES string

OC(=O)C(Cl)Cl

InChI

1S/C2H2Cl2O2/c3-1(4)2(5)6/h1H,(H,5,6)

InChI key

JXTHNDFMNIQAHM-UHFFFAOYSA-N

Gene Information

human ... ALDH1A1(216) , PDK1(5163)
rat ... Pdk1(116551)

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General description

filtered through a 1 μm filter

Application

Reagent used in the phosphite triester method of oligonucleotide synthesis for the cleavage of the 5′-protecting group. Reagent is suitable for use on Milligen 7500 synthesizers or as a more mildly acidic alternative to trichloroacetic acid.

signalword

Danger

Hazard Classifications

Carc. 2 - Eye Dam. 1 - Lact. - Repr. 1B - Skin Irrit. 2 - STOT SE 3

target_organs

Central nervous system

Storage Class

6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter

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Mehdi D Esrafili
Journal of molecular modeling, 18(12), 5005-5016 (2012-06-28)
A theoretical study was performed to examine hydrogen and halogen bonds properties in gas phase and crystalline dichloroacetic acid (DCAA). The specific pattern of O-H∙∙∙O, C-H∙∙∙O, HCl, Cl∙∙∙O and Cl∙∙∙Cl interactions in DCAA dimers is described within the quantum theory
Yi-Hsueh Chuang et al.
Water research, 47(3), 1308-1316 (2013-01-05)
The direct incorporation of chloramines and dissolved organic nitrogen (DON) may provide the nitrogen for nitrogenous disinfection byproducts (N-DBPs). This study explores the contributions of natural DON and chloramine incorporation to the formation of N-DBPs during chloramination. This study also
Alfredo Caro-Maldonado et al.
Journal of immunology (Baltimore, Md. : 1950), 192(8), 3626-3636 (2014-03-13)
B cell activation leads to proliferation and Ab production that can protect from pathogens or promote autoimmunity. Regulation of cell metabolism is essential to support the demands of lymphocyte growth and effector function and may regulate tolerance. In this study
Lin Piao et al.
Journal of molecular medicine (Berlin, Germany), 91(3), 333-346 (2012-12-19)
Pyruvate dehydrogenase kinase (PDK) is activated in right ventricular hypertrophy (RVH), causing an increase in glycolysis relative to glucose oxidation that impairs right ventricular function. The stimulus for PDK upregulation, its isoform specificity, and the long-term effects of PDK inhibition
Haihua Xiao et al.
Chemical communications (Cambridge, England), 48(87), 10730-10732 (2012-09-27)
A multifunctional hybrid platinum(IV) prodrug, which consists of both the mitochondria-targeting drug DCA and the DNA-crosslinking drug cisplatin, was synthesized and tethered to a carrier polymer to further self-assemble into micelles for intracellular delivery.
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