46609

Penicillin G potassium salt

VETRANAL^®, analytical standard

• Synonym(s): Benzylpenicillin potassium salt
• Empirical Formula (Hill Notation): C₁₆H₁₇KN₂O₄S
• CAS Number: 113-98-4
• Molecular Weight: 372.48
• Beilstein/REAXYS Number: 3832841
• EC Number: 204-038-0
• MDL number: MFCD00036193
• UNSPSC Code: 41116107
• PubChem Substance ID: 329757219
• E Number: E705
• NACRES: NA.24

Properties

• grade: analytical standard
• Quality Level: 100
• agency: EPA 1694
• product line: VETRANAL^®
• shelf life: limited shelf life, expiry date on the label
• technique(s): HPLC: suitable; gas chromatography (GC): suitable
• antibiotic activity spectrum: Gram-positive bacteria
• application(s): cleaning products; clinical; cosmetics; environmental; food and beverages; forensics and toxicology; personal care; pharmaceutical (small molecule)
• format: neat
• mode of action: cell wall synthesis | interferes
• storage temp.: 2-8°C
• SMILES string: [K+].[H][C@]12SC(C)(C)[C@@H](N1C(=O)[C@H]2NC(=O)Cc3ccccc3)C([O-])=O
• InChI: 1S/C16H18N2O4S.K/c1-16(2)12(15(21)22)18-13(20)11(14(18)23-16)17-10(19)8-9-6-4-3-5-7-9;/h3-7,11-12,14H,8H2,1-2H3,(H,17,19)(H,21,22);/q;+1/p-1/t11-,12+,14-;/m1./s1
• InChI key: IYNDLOXRXUOGIU-LQDWTQKMSA-M

Description

General description

Chemical structure: ß-lactam

Application

Penicillin G is a narrow spectrum antibiotic derived from Streptococcus pneumoniae. It is the drug of choice for groups A, B, C and G streptococci, nonenterococcal group D streptococci, viridians group streptococci, and non-penicillinase producing staphylococcus. The potassium salt has been used to study murosomes of staphylococci and the penicillin-induced lysis of Streptococcus mutans.

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Biochem/physiol Actions

Mode of Action: Penicillin G acts by inhibiting cell wall synthesis through binding to penicillin binding proteins (PBPs), inhibiting peptidoglycan chain cross-linking.

Antimicrobial spectrum: This product is active against gram-positive and gram-negative bacteria.

Caution

Solutions should be filter sterilized and stored at 2-8°C for 1 week or at -20°C for more lengthy periods. Solutions are stable at 37°C for 3 days. The sodium salt is soluble in H₂O at 100 mg/mL.

Legal Information

VETRANAL is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• pictograms: GHS07
• signalword: Warning
• hcodes: H317
• pcodes: P261 - P272 - P280 - P302 + P352 - P333 + P313 - P362 + P364
• Hazard Classifications: Skin Sens. 1
• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 2
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: dust mask type N95 (US), Eyeshields, Faceshields, Gloves