27028

Sodium cholate hydrate

≥96.0% (dry matter, NT)

• Synonym(s): 3α,7α,12α-Trihydroxy-5β-cholan-24-oic acid sodium salt, Cholalic acid sodium salt
• Empirical Formula (Hill Notation): C₂₄H₃₉NaO₅ · xH₂O
• CAS Number: 206986-87-0
• Molecular Weight: 430.55 (anhydrous basis)
• Beilstein/REAXYS Number: 3582354
• EC Number: 206-643-5
• MDL number: MFCD00150749
• UNSPSC Code: 12352200

Properties

• description: anionic
• assay: ≥96.0% (dry matter, NT)
• optical activity: [α]20/D +35±2°, c = 0.6% in ethanol (dry matter)
• mol wt: micellar avg mol wt 900-1300
• aggregation number: 2-3
• impurities: ~4% water
• CMC: 9-15 mM (20-25°C)
• solubility: H₂O: 0.1 M, clear
• anion traces: chloride (Cl^-): ≤50 mg/kg; sulfate (SO₄^2-): ≤50 mg/kg
• cation traces: Ca: ≤10 mg/kg; Cd: ≤5 mg/kg; Co: ≤5 mg/kg; Cr: ≤5 mg/kg; Cu: ≤5 mg/kg; Fe: ≤5 mg/kg; K: ≤50 mg/kg; Mg: ≤5 mg/kg; Mn: ≤5 mg/kg; Ni: ≤5 mg/kg; Pb: ≤5 mg/kg; Zn: ≤5 mg/kg
• HLB: 18
• SMILES string: O.[Na+].C[C@H](CCC([O-])=O)C1CCC2C3[C@H](O)CC4C[C@H](O)CC[C@]4(C)C3C[C@H](O)[C@]12C
• InChI: 1S/C24H40O5.Na.H2O/c1-13(4-7-21(28)29)16-5-6-17-22-18(12-20(27)24(16,17)3)23(2)9-8-15(25)10-14(23)11-19(22)26;;/h13-20,22,25-27H,4-12H2,1-3H3,(H,28,29);;1H2/q;+1;/p-1/t13-,14+,15-,16-,17+,18+,19-,20+,22+,23+,24-;;/m1../s1
• InChI key: MUVVIYFKOVLQHL-RCVKHMDESA-M

Description

application

Sodium cholate hydrate was used in the sonication and purification of single-walled carbon nanotubes prior to electrophoresis.[1][2]

Biochem/physiol Actions

Sodium cholate is an anionic detergent. It forms aggregates or micelles in aqueous solution.[3] It slightly increases the solubility of insoluble molecules such as cholesterol, phospholipids and fatty acids.[4]

Preparation Note

Sodium cholate hydrate yields clear, colorless solution in water (0.1 M).