Hexacosanoic acid is classified under the very long chain fatty acids (VLCFAs) group of biologically important compounds.[1]
Application
Hexacosanoic acid may be used as a reference standard for the determination of hexacosanoic acid
in human serum and plasma samples for the screening of peroxisomal disorders by gas chromatography-mass spectrometry (GC-MS) operating under selected-ion monitoring (SIM) mode[2]
Gas chromatography/mass spectrometry analysis of very long chain fatty acids, docosahexaenoic acid, phytanic acid and plasmalogen for the screening of peroxisomal disorders.
Takemoto Y, et al.
Brain & Development, 25(7), 481-487 (2003)
A fluorimetric liquid chromatography for highly sensitive analysis of very long chain fatty acids as naphthoxyethyl derivatives.
Lu CY, et al.
Chromatographia, 51(5-6), 315-321 (2000)
Separation of triacylglycerols and free fatty acids in microalgal lipids by solid-phase extraction for separate fatty acid profiling analysis by gas chromatography.
Paik MJ, et al.
Journal of Chromatography A, 1216(31), 5917-5923 (2009)
High sensitivity quantitative lipidomics analysis of fatty acids in biological samples by gas chromatography-mass spectrometry.
Quehenberger O, et al.
Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, 1811(11), 648-656 (2011)
Biochimica et biophysica acta, 1852(5), 925-936 (2015-01-15)
X-linked adrenoleukodystrophy (X-ALD) is a severe neurodegenerative disorder resulting from defective ABCD1 transport protein. ABCD1 mediates peroxisomal uptake of free very-long-chain fatty acids (VLCFA) as well as their CoA-esters. Consequently, VLCFA accumulate in patients' plasma and tissues, which is considered
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