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01870575

Sennoside A

primary reference standard

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About This Item

Empirical Formula (Hill Notation):
C42H38O20
CAS Number:
81-27-6
Molecular Weight:
862.74
Beilstein/REAXYS Number:
5723746
EC Number:
201-339-9
MDL number:
MFCD00151527
UNSPSC Code:
85151701
PubChem Substance ID:
329747365
NACRES:
NA.24

grade

primary reference standard

shelf life

limited shelf life, expiry date on the label

manufacturer/tradename

HWI

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

food and beverages

SMILES string

OC[C@H]1O[C@@H](Oc2cccc3[C@@H]([C@@H]4c5cccc(O[C@H]6O[C@H](CO)[C@@H](O)[C@H](O)[C@H]6O)c5C(=O)c7c(O)cc(cc47)C(O)=O)c8cc(cc(O)c8C(=O)c23)C(O)=O)[C@H](O)[C@@H](O)[C@@H]1O

InChI

1S/C42H38O20/c43-11-23-31(47)35(51)37(53)41(61-23)59-21-5-1-3-15-25(17-7-13(39(55)56)9-19(45)27(17)33(49)29(15)21)26-16-4-2-6-22(60-42-38(54)36(52)32(48)24(12-44)62-42)30(16)34(50)28-18(26)8-14(40(57)58)10-20(28)46/h1-10,23-26,31-32,35-38,41-48,51-54H,11-12H2,(H,55,56)(H,57,58)/t23-,24-,25-,26-,31-,32-,35+,36+,37-,38-,41-,42?/m1/s1

InChI key

IPQVTOJGNYVQEO-GTCVFCFLSA-N

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General description

Produced and qualified by HWI pharma services GmbH.
Exact content by quantitative NMR can be found on the certificate.

Application

Reference standard in the analysis of herbal medicinal products.

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H302

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
HWI00196-8
HWI00196-7
HWI00196-6
HWI00196-5
HWI00196-4

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Acute hemorrhagic colitis following administration of sennosides for colon cleansing.
Burhan Ozdil et al.
The Annals of pharmacotherapy, 44(4), 770-771 (2010-03-25)
Manuk N Manukyan et al.
Surgical laparoscopy, endoscopy & percutaneous techniques, 21(2), 90-93 (2011-04-08)
The aim of this study is to assess 2 different bowel-cleansing agents. The patients were prospectively randomized to 2 arms of sodium phosphate versus Sennoside A+B calcium preparation. Laboratory assessment, body weight, height, and vital signs were obtained at baseline
Philippa Helen Hawley et al.
Journal of palliative medicine, 11(4), 575-581 (2008-05-06)
Constipation is a common and distressing condition in patients with cancer, especially those taking opioid analgesics. Many institutions prevent and treat constipation with titrated laxatives, which is known as a bowel protocol. An effective and well-tolerated bowel protocol is a
Constipation and aspiration pneumonia.
Maki Takahashi et al.
Geriatrics & gerontology international, 12(3), 570-571 (2012-06-21)
Katsuhiro Yamasaki et al.
Journal of natural medicines, 64(2), 126-132 (2010-01-22)
The sennoside A (SA) and sennoside B (SB) contents of various samples of crude drugs were determined using solid-phase extraction (SPE) and HPLC. The samples examined were crude drugs (senna leaf, senna pods, and rhubarb), conventional crude drug products, and
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