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PC388

Sigma-Aldrich

Anti-hMre-11 Rabbit pAb

liquid, Calbiochem®

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About This Item

UNSPSC Code:
12352203

biological source

rabbit

antibody product type

primary antibodies

clone

polyclonal

form

liquid

contains

≤0.1% sodium azide as preservative

species reactivity

mouse, rat, human

manufacturer/tradename

Calbiochem®

storage condition

do not freeze

isotype

IgG

shipped in

wet ice

storage temp.

2-8°C

General description

This product has been discontinued.



Recognizes the ~85 kDa hMre-11 protein in IMR90 and K562 cells.

Affinity purified rabbit polyclonal antibody. Recognizes the ~85 kDa hMre-11 protein.
Anti-hMre-11, rabbit polyclonal, recognizes the ~85 kDa hMre-11 protein in IMR90 and K562 cells. It is validated for use in Western blotting, immunofluorescence, and immunoprecipitation.

Immunogen

Human
recombinant, human hMre11 protein

Application


Immunoblotting (1 g/ml)
Immunofluorescence (1 g/ml)
Immunoprecipitation (1 g/reaction)

Packaging

Please refer to vial label for lot-specific concentration.

Warning

Toxicity: Standard Handling (A)

Physical form

In 50 mM sodium phosphate buffer, 0.2% gelatin, pH 7.5.

Analysis Note

Positive Control
IMR90 or K562 cells

Other Notes

Antibody should be titrated for optimal results in individual systems.
Dong, Z., et al. 1999. J. Biol. Chem.274, 19513.
Luo, G., et al. 1999. Proc. Natl. Acad. Sci. USA96, 7376.
Petrini, J.H. 1999. Am. J. Hum. Genet.64, 1264.
Carney, J.P., et al. 1998. Cell93, 477.
Haber, J.E. 1998. Cell95, 583.
Nelms, B.E., et al. 1998. Science280, 590.
Maser, R.S., et al. 1997. Mol. Cell Biol.17, 6087.
Xiao, Y. and D.T. Weaver. 1997. Nucleic Acids Res.25, 2985.
Dolganov, G.M., et al. 1996. Mol. Cell Biol.16, 4832.
Petrini, J.H., et al. 1995. Genomics29, 80.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

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Storage Class

10-13 - German Storage Class 10 to 13


Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Z Dong et al.
The Journal of biological chemistry, 274(28), 19513-19516 (1999-07-03)
The Nijmegen breakage syndrome (NBS), a chromosomal instability disorder, is characterized in part by cellular hypersensitivity to ionizing radiation. Repair of DNA double-strand breaks by radiation is dependent on a multifunctional complex containing Rad50, Mre11, and the NBS1 gene product
R S Maser et al.
Molecular and cellular biology, 17(10), 6087-6096 (1997-10-07)
We previously identified a conserved multiprotein complex that includes hMre11 and hRad50. In this study, we used immunofluorescence to investigate the role of this complex in DNA double-strand break (DSB) repair. hMre11 and hRad50 form discrete nuclear foci in response
Y Xiao et al.
Nucleic acids research, 25(15), 2985-2991 (1997-08-01)
Repair of DNA damage resulting in double-strand breaks (DSBs) is controlled by gene products executing homologous recombination or end-joining pathways. The MRE11 gene has previously been implicated in DSB repair in the yeast Saccharomyces cerevisiae . Here we have developed
The many interfaces of Mre11.
J E Haber
Cell, 95(5), 583-586 (1998-12-09)
The mammalian Mre11-Rad50-nbs1 protein complex: integration of functions in the cellular DNA-damage response.
J H Petrini
American journal of human genetics, 64(5), 1264-1269 (1999-04-17)

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