Retinoic acid-induced protein 17 (RAI17) is also called Zinc finger MIZ domain-containing protein 1 (ZMIZ1), and PIAS-like protein Zimp10. Retinoic acid-induced protein 17 promotes AR sumoylation and increases AR ligand-dependent transcriptional activity. Retinoic acid-induced protein 17 is highly expressed in ovary and at lower levels in prostate, spleen and testis.
Immunogen
Recombinant protein corresponding to human RA-induced protein 17.
Application
Detect Retinoic acid-induced protein 17 using this mouse monoclonal antibody, Anti-RA-induced protein 17 Antibody, clone 5H5.1 validated for use in western blotting & IHC.
Immunohistochemistry Analysis: A 1:50 dilution from a representative lot detected RA-induced protein 17 in human thalamus tissue.
Research Category Neuroscience
Research Sub Category Developmental Signaling
Quality
Evaluated by Western Blotting in SH-SY5Y cell lysate.
Western Blotting Analysis: 0.5 µg/mL of this antibody detected RA-induced protein 17 in 10 µg of SH-SY5Y cell lysate.
Target description
~115 kDa observed. Uniprot describes 2 isoforms produced by alternative splicing at ~115 kDa and ~107 kDa
Physical form
Format: Purified
Protein G Purified
Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Storage and Stability
Stable for 1 year at 2-8°C from date of receipt.
Other Notes
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class
12 - Non Combustible Liquids
wgk_germany
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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Proceedings of the National Academy of Sciences of the United States of America, 118(18) (2021-04-29)
Loss of the fragile X mental retardation protein (FMRP) causes fragile X syndrome (FXS). FMRP is widely thought to repress protein synthesis, but its translational targets and modes of control remain in dispute. We previously showed that genetic removal of
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