MAB2642

Anti-Fibrillin-2 Antibody, clone 48

clone 48, from mouse

• Synonym(s): fibrillin 2, congenital contractural arachnodactyly, Fibrillin 5
• UNSPSC Code: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

Properties

• biological source: mouse
• Quality Level: 100
• antibody form: purified antibody
• antibody product type: primary antibodies
• clone: 48, monoclonal
• species reactivity: human
• technique(s): ELISA: suitable; immunocytochemistry: suitable; immunohistochemistry: suitable; immunoprecipitation (IP): suitable
• isotype: IgG1κ
• NCBI accession no.: NP_001990
• UniProt accession no.: P35556
• shipped in: wet ice
• target post-translational modification: unmodified
• Gene Information: human ... FBN2(2201)

Description

General description

Fibrillin-2 is a part of the Fibrillin family of glycoproteins, which are essential factors in the formation and maintenance of elastic fibers known as microfibrils within the extracellular matrix. Various researchers have suggested that Fibrillin-2 has a role in the mediation of microfibril assembly during early elastogenesis. Defects in Fibrillin-2 are causal to a rare disorder involving autosomal dominant connective tissue known as congenital contractual arachnodactyly (CCA), also known as Beals syndrome or distal arthrogryposis type 9 (DA9), and is similar to Marfan syndrome.

Specificity

The antibody recognizes Fibrillin-2.

Immunogen

Recombinant protein corresponding to human Fibrillin-2.

Application

Anti-Fibrillin-2 Antibody, clone 48 is an antibody against Fibrillin-2 for use in IH, ELISA, IP & IC.

ELISA Analysis: A previous lot was used by an independent laboratory in ELISA (Charbonneau, 2003).

Immunofluorescence Analysis: A previous lot was used by an independent laboratory in IF (Charbonneau, 2003).

Quality

Evaluated by Immunohistochemistry in liver cancer and papillary serous carcinoma paraffin-embedded tissue sections.

Immunohistochemistry Analysis: 1:50 dilution of this antibody detected Fibrillin-2 in paraffin-embedded tissue sections of liver cancer and papillary serous carcinoma.

Target description

~ 215 kDa

Physical form

Format: Purified

Analysis Note

Control
Liver cancer and papillary serous carcinoma tissue

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Safety Information

• Storage Class: 12 - Non Combustible Liquids
• wgk_germany: WGK 1
• flash_point_f: Not applicable
• flash_point_c: Not applicable