GF442-M
HumanKine® TNF alpha, Human Recombinant Xeno-Free
Synonym(s):
Tumor Necrosis Factor-α, TNFa
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About This Item
UNSPSC Code:
12352202
eCl@ss:
32160405
NACRES:
NA.77
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General description
Tumor necrosis factor alpha (TNF-α), is the prototypic ligand of the TNF superfamily. It is a pleiotropic molecule that plays a central role in inflammation, apoptosis, and immune system development. TNF-α is produced by a wide variety of immune and epithelial cell types. It belongs to the TNF family of ligands and signals through two receptors, TNFR1 and TNFR2. TNF-α is cytotoxic to a wide variety of tumor cells and is an essential factor in mediating the immune response against bacterial infections. TNF-α also plays a role in the induction of septic shock, auto immune diseases, rheumatoid arthritis, inflammation, and diabetes.
Quality
Bioactivity assay: Determined by the dose-dependent cytotoxity of the TNF alpha sensitive cell line L-929 in the presence of
Actinomycin D. Typically <0.9 ng/mL ED50.
Actinomycin D. Typically <0.9 ng/mL ED50.
Physical form
HumanKine TNF alpha is manufactured using all non-animal reagents and is considered Xeno-Free
Legal Information
HumanKine is a registered trademark of Proteintech Group, Inc. and Humanzyme, Inc
Storage Class
13 - Non Combustible Solids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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