ABN87
Anti-DSCR3 Antibody
from rabbit, purified by affinity chromatography
Synonym(s):
Down syndrome critical region protein 3, Down syndrome critical region protein A
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About This Item
UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41
Recommended Products
biological source
rabbit
Quality Level
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
purified by
affinity chromatography
species reactivity
human
technique(s)
immunohistochemistry: suitable (paraffin)
western blot: suitable
NCBI accession no.
UniProt accession no.
shipped in
wet ice
target post-translational modification
unmodified
Gene Information
human ... VPS26C(10311)
General description
Trisomy of human chromosome 21 result in patients with Down′s syndrome, which is a complex developmental and neurodegenerative disease that is characterized with abnormal morphological features, hypotonia, and mental retardation. The DSCR3 (Down syndrome critical region gene 3) gene is found in this region. DSCR3 expresses Down syndrome critical region protein 3, which is reportedly expressed in many studied tissues. While it is suggested that this protein is involved in neuroexcitation and in cellular signaling, further study is still required to elucidate its role and mechanism of action.
Specificity
Other homologies: Rat and Mouse (92% sequence homology).
Immunogen
KLH-conjugated linear peptide corresponding to human DSCR3.
Application
Immunohistochemistry Analysis: A 1:200 dilution from a representative lot detected DSCR3 in human gastric tissue.
Research Category
Neuroscience
Neuroscience
Research Sub Category
Neurodegenerative Diseases
Neurodegenerative Diseases
This Anti-DSCR3 Antibody is validated for use in WB, IH(P) for the detection of DSCR3.
Quality
Evaluated by Western Blot in A549 cell lysate.
Western Blot Analysis: 0.5 µg/mL of this antibody detected DSCR3 in 10 µg of A549 cell lysate.
Western Blot Analysis: 0.5 µg/mL of this antibody detected DSCR3 in 10 µg of A549 cell lysate.
Target description
~39 kDa observed. An uncharacterized band may be observed at a molecular weight of ~160 kDa in some cell lysates.
Physical form
Affinity purified
Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Storage and Stability
Stable for 1 year at 2-8°C from date of receipt.
Analysis Note
Control
A549 cell lysate
A549 cell lysate
Other Notes
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class
12 - Non Combustible Liquids
wgk_germany
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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Kerrie E McNally et al.
Nature cell biology, 19(10), 1214-1225 (2017-09-12)
Following endocytosis into the endosomal network, integral membrane proteins undergo sorting for lysosomal degradation or are retrieved and recycled back to the cell surface. Here we describe the discovery of an ancient and conserved multiprotein complex that orchestrates cargo retrieval
Rebeka Butkovič et al.
Nature communications, 15(1), 7180-7180 (2024-08-22)
Commander is a multiprotein complex that orchestrates endosomal recycling of integral cargo proteins and is essential for normal development. While the structure of this complex has recently been described, how cargo proteins are selected for Commander-mediated recycling remains unclear. Here
Michael D Healy et al.
Cell, 186(10), 2219-2237 (2023-05-13)
The Commander complex is required for endosomal recycling of diverse transmembrane cargos and is mutated in Ritscher-Schinzel syndrome. It comprises two sub-assemblies: Retriever composed of VPS35L, VPS26C, and VPS29; and the CCC complex which contains twelve subunits: COMMD1-COMMD10 and the
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