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Key Documents

ABN354

Sigma-Aldrich

Anti-NIPSNAP2 Antibody

from rabbit, purified by affinity chromatography

Synonym(s):

Non-neuronal SNAP25-like protein 2, Glioblastoma-amplified sequence, GBAS

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About This Item

UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

biological source

rabbit

Quality Level

100

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

purified by

affinity chromatography

species reactivity

human, mouse

technique(s)

immunohistochemistry: suitable
western blot: suitable

UniProt accession no.

O75323

shipped in

wet ice

target post-translational modification

unmodified

Gene Information

human ... GBAS(2631)

General description

The NIPSNAP proteins comprise a family of evolutionarily well-conserved proteins with strong sequence similarity to the central portion of a protein encoded by C. elegans chromosome III between a 4-nitrophenylphosphatase (NIP) domain and non-neuronal SNAP25-like protein. NIPSNAP2, a novel gene encoding a protein with tyrosine phosphorylation sites and a transmembrane domain, is co-amplified with EGFR in approximately 40% of glioblastomas, the most common and malignant form of central nervous system tumors. It is widely expressed and most abundant in heart and skeletal muscle. NIPSNAP proteins have been suggested to be important in vesicular transport.

Specificity

NIPSNAP2 antibody is predicted to not cross-react with any other members of the NIPSNAP protein family.

Immunogen

KLH-conjugated linear peptide corresponding to human NIPSNAP2.

Application

Detect the NIPSNAP2 protein using this Anti-NIPSNAP2 validated for use in WB & IHC.
Immunohistochemistry Analysis: 2.5µg/mL of this antibody from a representative lot detected NIPSNAP2 in mouse skeletal muscle tissue.

Quality

Evaluated by Western Blot in human skeletal muscle tissue lysate.

Western Blotting Analysis: 1 µg/mL of this antibody detected NIPSNAP2 in 15 µg of human skeletal muscle tissue lysate.

Target description

~31 kDa observed

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

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Storage Class

12 - Non Combustible Liquids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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