MSL3, also known as Male-specific lethal 3 homolog, or Male-specific lethal-3 homolog 1, or Male-specific lethal-3 protein-like 1 (MSL3-like 1), and encoded by the gene MSL3/MSL3L1, is a component of the MSL(male-specific lethal ) histone acetyltransferase complex which is responsible for the majority of histone H4 acetylation at ′Lys-16′ which is implicated in the formation of higher-order chromatin structure. MSL3 may also be involved in chromatin remodeling and transcriptional regulation. Additionally, MSL3 may have a role in X inactivation as its gene is a target for X inactivation. MSL3 is localized to the nucleus. MSL3 is expressed in many tissues including liver, pancreas, heart, lung, kidney, skeletal muscle, brain, and placenta, with highest expression in skeletal muscle and heart.
Immunogen
Linear peptide corresponding to human MSL3-like 1.
Application
Chromatin Immunoprecipitation Analysis: A representative lot from an independent laboratory immunoprecipitated MSL3-like 1 from HeLa cell lysate (Wu, L., et al. (2011). Mol Cell. 43(1):132-144.).
Detect MSL3-like 1 using this Anti-MSL3-like 1 antibody validated for use in western blotting & ChIP.
Quality
Evaluated by Western Blotting in Jurkat cell lysate.
Western Blotting Analysis: 1 µg/mL of this antibody detected MSL3-like 1 in 10 µg of Jurkat cell lysate.
Target description
~58 kDa observed. Five isoforms are known to exist at 60 kDa (isoform 1), 53 kDa (isoform 2), 58 kDa (isoform 3), 40 kDa (isoform 4), and 48 kDa (isoform 5).
Physical form
Format: Purified
Other Notes
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
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Storage Class
12 - Non Combustible Liquids
wgk_germany
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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