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Key Documents

AB4350

Sigma-Aldrich

Anti-PRDM14 Antibody

from rabbit, purified by affinity chromatography

Synonym(s):

PR domain zinc finger protein 14, PR domain-containing protein 14

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About This Item

UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

biological source

rabbit

Quality Level

100

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

purified by

affinity chromatography

species reactivity

rat, mouse, human

technique(s)

western blot: suitable

NCBI accession no.

NP_078780

UniProt accession no.

Q9GZV8

shipped in

wet ice

target post-translational modification

unmodified

Gene Information

human ... PRDM14(63978)

General description

PR domain proteins (PRDMs) have been associated with many types of human cancers. PRDM14 was found to be up-regulated in breast cancer cells. The expression of PRDM14 to breast cancer cells actually increased cell proliferation and decreased the effect of chemotherapeutic drugs, while down-regulation of PRDM14 did the opposite. In addition to breast cancer, PRDM14 has recently been linked to non-small cell lung cancer development. PRDM14 also seems to play a role in the preservation of the self-renewal of human embryonic stem cells and transcriptional regulation.

Specificity

This antibody recognizes the N-terminus of PRDM14.

Immunogen

GST-tagged recombinant protein corresponding to the N-terminus of human PRDM14.

Application

This Anti-PRDM14 Antibody is validated for use in WB for the detection of PRDM14.

Quality

Evaluated by Western Blot in human lung tissue lysate.

Western Blot Analysis: A 1:1000 dilution of this antibody detected PRDM14 in 10 µg of human lung tissue lysate.

Target description

~62 kDa observed

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Storage Class

12 - Non Combustible Liquids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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SOX17 is a critical specifier of human primordial germ cell fate.
Irie, N; Weinberger, L; Tang, WW; Kobayashi, T; Viukov, S; Manor, YS; Dietmann, S; Hanna et al.
Cell null
Yu Kang et al.
Cell reports, 25(9), 2563-2576 (2018-11-30)
Monkeys are an optimal model species for developing stem cell therapies. We previously reported generating chimeric cynomolgus monkey fetuses using dome-shaped embryonic stem cells (dESCs). However, conventional primed pluripotent stem cells (pPSCs) lack chimera competency. Here, by altering the media
Pengyi Yang et al.
Cell systems, 8(5), 427-445 (2019-05-13)
Pluripotency is highly dynamic and progresses through a continuum of pluripotent stem cell states. The two states that bookend the pluripotency continuum, naive and primed, are well characterized, but our understanding of the intermediate states and transitions between them remains

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