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8.55130

Sigma-Aldrich

Rink Amide AM resin (100-200 mesh)

Novabiochem®

Synonym(s):

Rink Amide AM resin (100-200 mesh), 4-(2′,4′-Dimethoxyphenyl-Fmoc-aminomethyl)-phenoxyacetamido-aminomethyl resin

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About This Item

CAS Number:
183599-10-2
UNSPSC Code:
12352111
NACRES:
NA.22

Quality Level

400

product line

Novabiochem®

form

powder

reaction suitability

reaction type: Fmoc solid-phase peptide synthesis

manufacturer/tradename

Novabiochem®

application(s)

peptide synthesis

functional group

amine

storage temp.

2-30°C

General description

This support comprises the modified Rink amide linker attached to aminomethylpolystyrene and is an ideal tool for the Fmoc SPPS of peptide amides. Cleavage from this resin can be effected by a single step treatment with 95% TFA, providing peptide amides in high yields and purities.

Associated Protocols and Technical Articles
Protocols for Loading of Peptide Synthesis Resins

Application

Applications of Rink Amide AM resin (100-200 mesh)in solid phase organic synthesis include:
  • In the synthesis of quinazolinone derivatives via intramolecular transamidation.
  • In the preparation of 2-aminoquinazoline-based compounds using solid-phase peptide synthesis (SPPS) methodology.
  • For the synthesis of α-aryl ketones via a palladium-catalyzed coupling reaction.

Legal Information

Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany

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Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

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Articles

Fmoc SPPS Linkers

Novabiochem® offers a wide range of linkers and derivatized resins for Fmoc solid-phase peptide synthesis with specialized protocols.

Protocols

Peptide Resin Loading Protocols

Review various resins like Merrifield, trityl-based, and hydroxymethyl-functionalized for peptide immobilization for diverse applications.

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

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