8.55050

Dansyl NovaTag^® resin

Novabiochem^®

• Synonym(s): N-Dansyl-NÆ-Fmoc-ethylenediamine MPB-AM resin
• UNSPSC Code: 12352116
• NACRES: NA.22

Properties

• Quality Level: 200
• product line: NovaSyn^® TG; Novabiochem^®
• form: beads
• reaction suitability: reaction type: Fmoc solid-phase peptide synthesis
• manufacturer/tradename: Novabiochem^®
• application(s): peptide synthesis
• functional group: amine
• storage temp.: 15-25°C

Description

General description

Dansyl NovaTag resin is an ideal tool for the synthesis of Dansyl-labeled peptides. The resin pre-loaded with the Dansyl chromophore can be used directly in Fmoc SPPS. Following peptide assembly under standard Fmoc SPPS conditions, cleavage with TFA affords the Dansyl-labeled peptide. This resin has been recently used to dansyl-labeled amyloid-RGD peptides ^[1] and FRET probes for mercury binding protein MerP ^[2].

Associated Protocols and Technical Articles
Protocols for Loading of Peptide Synthesis Resins

Literature references

^[1] S. L. Gras, et al. (2008) Biomaterials, 29, 1553.
^[2] B. R. White, et al. (2008) Analyst,, 133, 65

Linkage

Replaces: 04-12-3900

Analysis Note

Color (visual): white to yellow to beige
Appearance of substance (visual): beads
Loading (Photometric determination of the Fmoc-chromophore liberated upon treatment with DBU/DMF): 0.30 - 0.60 mmol/g
Swelling Volume (in DMF): lot specific result
The polymer matrix is copoly styrene - 1 & DVB 100 - 200 mesh

Legal Information

NOVASYN is a registered trademark of Merck KGaA, Darmstadt, Germany

NOVATAG is a registered trademark of Merck KGaA, Darmstadt, Germany

Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 1
• flash_point_f: Not applicable
• flash_point_c: Not applicable