8.52371

Fmoc-His(Clt)-OH

for peptide synthesis, Novabiochem

• Synonym(s): Fmoc-His(Clt)-OH, N-α-Fmoc-N-im-2-chlorotrityl-L-histidine
• Empirical Formula (Hill Notation): C₄₀H₃₂ClN₃O₄
• CAS Number: 224032-19-3
• Molecular Weight: 654.15
• UNSPSC Code: 12352209

Properties

• product name: Fmoc-His(Clt)-OH, Novabiochem^®
• product line: Novabiochem^®
• form: powder
• reaction suitability: reaction type: Fmoc solid-phase peptide synthesis
• manufacturer/tradename: Novabiochem^®
• application(s): peptide synthesis
• functional group: Fmoc
• storage temp.: 15-25°C
• InChI: 1S/C40H32ClN3O4/c41-36-22-12-11-21-35(36)40(27-13-3-1-4-14-27,28-15-5-2-6-16-28)44-24-29(42-26-44)23-37(38(45)46)43-39(47)48-25-34-32-19-9-7-17-30(32)31-18-8-10-20-33(31)34/h1-22,24,26,34,37H,23,25H2,(H,43,47)(H,45,46)/t37-/m0/s1
• InChI key: SYGADBVEKBWUKO-QNGWXLTQSA-N

Description

General description

A useful derivative for the convergent synthesis of peptide due to the enhanced stability of Clt group compared to Trt group to mildy acidic reagents. Fmoc-His-(Clt)-OH gives approximately a third less racemization when compared to Fmoc-His(Trt)-OH during slow coupling reactions.

Associated Protocols and Technical Articles
Cleavage and Deprotection Protocols for Fmoc SPPS

Legal Information

Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 2
• flash_point_c: Not applicable