681636-M

W-13, Hydrochloride

A cell-permeable and reversible calmodulin antagonist that inhibits myosin light chain kinase (IC₅₀ = 58 µM) and Ca²⁺-calmodulin-dependent phosphodiesterase (IC₅₀ = 68 µM).

• Synonym(s): W-13, Hydrochloride, N-(4-Aminobutyl)-5-chloro-2-naphthalenesulfonamide, HCl
• Empirical Formula (Hill Notation): C₁₄H₁₇ClN₂O₂S · xHCl
• CAS Number: 88519-57-7
• Molecular Weight: 312.81 (free base basis)
• MDL number: MFCD00058030
• UNSPSC Code: 12352200

Properties

• Quality Level: 100
• assay: ≥98% (HPLC)
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze; desiccated (hygroscopic); protect from light
• color: white
• solubility: water: 35 mg/mL
• storage temp.: 2-8°C
• SMILES string: [S](=O)(=O)(NCCCCN)c1cc2c(c(ccc2)Cl)cc1.Cl
• InChI: 1S/C14H17ClN2O2S.ClH/c15-14-5-3-4-11-10-12(6-7-13(11)14)20(18,19)17-9-2-1-8-16;/h3-7,10,17H,1-2,8-9,16H2;1H
• InChI key: QKAALLVQBOLELJ-UHFFFAOYSA-N

Description

General description

A cell-permeable and reversible calmodulin antagonist that inhibits Ca²⁺-calmodulin-dependent phosphodiesterase (IC₅₀ = 68 µM) and myosin light chain kinase (IC₅₀ = 58 µM).

A cell-permeable and reversible calmodulin antagonist that inhibits myosin light chain kinase (IC₅₀ = 58 µM) and Ca²⁺-calmodulin-dependent phosphodiesterase (IC₅₀ = 68 µM).

Biochem/physiol Actions

Target IC₅₀: 58 µM, 68 µM, against myosin light chain kinase and Ca2+-calmodulin-dependent phosphodiesterase

Warning

Toxicity: Standard Handling (A)

Analysis Note

single spot by TLC

Other Notes

Hidaka, H., and Tanaka, T. 1983. Methods Enzymol. 102, 185.
Tanaka, T., et al. 1983. Pharmacol.26, 249.
Tanaka, T., and Hidaka, H. 1980. J. Biol. Chem. 255, 11078.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable