658452

AG 126

A cell-permeable inhibitor of lipopolysaccharide (LPS)-induced synthesis of tumor necrosis factor-α and nitric oxide in murine peritoneal macrophages.

• Synonym(s): AG 126, α-Cyano-(3-hydroxy-4-nitro)cinnamonitrile
• Empirical Formula (Hill Notation): C₁₀H₅N₃O₃
• CAS Number: 118409-62-4
• Molecular Weight: 215.17
• MDL number: MFCD00236448
• UNSPSC Code: 12352200
• NACRES: NA.77

Properties

• Quality Level: 100
• assay: ≥95% (HPLC)
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze; protect from light
• color: yellow
• solubility: DMSO: 5 mg/mL; DMF: soluble
• shipped in: ambient
• storage temp.: −20°C
• SMILES string: [N+](=O)([O-])c1c(cc(cc1)C=C(C#N)C#N)O
• InChI: 1S/C10H5N3O3/c11-5-8(6-12)3-7-1-2-9(13(15)16)10(14)4-7/h1-4,14H
• InChI key: DUQADSPERJRQBW-UHFFFAOYSA-N

Description

General description

A cell-permeable inhibitor of lipopolysaccharide (LPS)-induced synthesis of tumor necrosis factor-α and nitric oxide in murine peritoneal macrophages. Blocks LPS-induced tyrosine phosphorylation of a p42^MAPK/ERK2 protein substrate. Reduces the expression of iNOS and COX-2 in lungs of rats treated with carrageenan. Blocks glucocorticoid-induced COX-2 activity in human amnion cells (IC₅₀ = 15.38 µM).

Biochem/physiol Actions

Cell permeable: yes

Primary Target
COX-2 activity

Product does not compete with ATP.

Reversible: no

Target IC₅₀: 15.38 µM in blocking glucocorticoid-induced COX-2 activity in human amnion cells

Warning

Toxicity: Toxic (F)

Other Notes

Cuzzocrea, S., et al. 2000. Am. J. Pathol.157, 145.
Zakar, T., et al. 1999. Can. J. Physiol. Pharmacol.77, 138.
Kan, H., et al. 1996. Mol. Pharmacol.50, 1139.
Novogrodsky, A., et al. 1994. Science264, 1319.

Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3