648450-M
TrkA Inhibitor
The TrkA Inhibitor, also referenced under CAS 388626-12-8, controls the biological activity of TrkA. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
Synonym(s):
TrkA Inhibitor
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About This Item
Empirical Formula (Hill Notation):
C15H13N3O3S
CAS Number:
Molecular Weight:
315.35
UNSPSC Code:
12352200
Recommended Products
assay
≥97% (sum of two isomers, HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
protect from light
color
yellow
solubility
DMSO: 200 mg/mL
storage temp.
2-8°C
General description
A potent, cell-permeable, reversible, and highly selective inhibitor of TrkA (IC50 = 63 nM), presumably by targeting the ATP binding pocket. Shown to exhibit ≥150-fold selectivity over Cdk1 and cRaf1.
An oxindole compound that acts as a cell-permeable, reversible, potent, and highly selective inhibitor of TrkA (IC50 = 63 nM), presumably by targeting the kinase’s ATP binding pocket. Shown to exhibit ≥150-fold selectivity over Cdk1 and cRaf1.
Biochem/physiol Actions
Primary Target
TrkA
TrkA
Target IC50: 63 nM against TrkA
Warning
Toxicity: Standard Handling (A)
Reconstitution
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Other Notes
Wood, E.R., et al. 2004. Bioorg. Med. Chem. Lett.14, 953.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Storage Class
11 - Combustible Solids
wgk_germany
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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