565777

γ-Secretase Inhibitor XVI

The γ-Secretase Inhibitor XVI, also referenced under CAS 208255-51-0, controls the biological activity of γ-Secretase. This small molecule/inhibitor is primarily used for Neuroscience applications.

• Synonym(s): γ-Secretase Inhibitor XVI, DAPM, N-[N-3,5-Difluorophenacetyl]-L-alanyl-S-phenylglycine Methyl Ester
• Empirical Formula (Hill Notation): C₂₀H₂₀F₂N₂O₄
• CAS Number: 208255-51-0
• Molecular Weight: 390.38
• UNSPSC Code: 12352200

Properties

• Quality Level: 100
• assay: ≥97% (HPLC)
• form: solid
• potency: 10 nM IC₅₀
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze; protect from light
• color: white
• solubility: DMSO: 2 mg/mL
• shipped in: ambient
• storage temp.: 2-8°C
• InChI: 1S/C20H20F2N2O4/c1-12(23-17(25)10-13-8-15(21)11-16(22)9-13)19(26)24-18(20(27)28-2)14-6-4-3-5-7-14/h3-9,11-12,18H,10H2,1-2H3,(H,23,25)(H,24,26)/t12-,18-/m0/s1
• InChI key: XAPDRNSTUYCSQC-SGTLLEGYSA-N

Description

General description

A cell-permeable γ-secretase inhibitor (IC₅₀ Aβ = ~10 nM in 7PA2 cells) with anti-aggregation properties. Prevents early Aβ oligomerization by selectively blocking the Aβ dimer and trimer formation.

A cell-permeable γ-secretase inhibitor that inhibits Aβ secretion (IC₅₀ ~10 nM) by 7PA2 cells (CHO cell line stably transfected with APP751 containing V717F familial Alzheimer′s disease mutation) in a dose-dependent manner. Also exhibits anti-aggregation properties by selectively blocking Aβ dimer and trimer formation and subsequently preventing early Aβ oligomerization.

Biochem/physiol Actions

Cell permeable: yes

Primary Target
γ-secretase Aβ₄₀ in 7PA2 cells

Product does not compete with ATP.

Reversible: no

Packaging

Packaged under inert gas

Warning

Toxicity: Standard Handling (A)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.

Other Notes

Walsh, D.M., et al. 2002. Nature 416, 535.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 1
• flash_point_f: Not applicable
• flash_point_c: Not applicable