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Sigma-Aldrich

SB 328437

A highly potent and selective CC chemokine receptor-3 (CCR3) antagonist.

Synonym(s):

SB 328437, (S)-Methyl-2-naphthoylamino-3-(4-nitrophenyl)propionate

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About This Item

Empirical Formula (Hill Notation):
C21H18N2O5
CAS Number:
Molecular Weight:
378.38
MDL number:
UNSPSC Code:
12352200

Quality Level

assay

≥98% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
protect from light

color

white

solubility

DMSO: 100 mg/mL

shipped in

ambient

storage temp.

−20°C

InChI

1S/C21H18N2O5/c1-28-21(25)19(13-14-9-11-16(12-10-14)23(26)27)22-20(24)18-8-4-6-15-5-2-3-7-17(15)18/h2-12,19H,13H2,1H3,(H,22,24)/t19-/m0/s1

InChI key

VMFGCGRAIBLAFY-IBGZPJMESA-N

General description

A highly potent and selective CC chemokine receptor-3 (CCR3) antagonist that acts as a high affinity, competitive inhibitor of 125I-eotaxin and 125I-MCP-4 binding to human eosinophils. Inhibits eotaxin-, eotaxin-2-, and MCP-4-mediated human eosinophil chemotaxis (IC50 = 32, 25, and 55 nM, respectively) and calcium mobilization in CCR3-transfected RBL-2H3 cells (IC50 = 38, 35, and 20 nM, respectively).
A highly potent and selective CC chemokine receptor-3 (CCR3) antagonist. Inhibits calcium mobilization induced by eotaxin, eotaxin-2, or MCP-4 with IC50 values of 38, 35, and 20 nM, respectively. Also inhibits eotaxin, eotaxin-2, and MCP-4-mediated chemotaxis (IC50 values: 32, 25, and 55 nM, respectively).

Biochem/physiol Actions

Cell permeable: no
Primary Target
CC chemokine receptor-3 (CCR3)
Product does not compete with ATP.
Reversible: no
Target IC50: 38, 35, and 20 nM against calcium mobilization induced by eotaxin, eotaxin-2, or MCP-4, respectively

Packaging

Packaged under inert gas

Warning

Toxicity: Standard Handling (A)

Reconstitution

Following reconstitution, aliquot and freeze at -20°C. Stock solutions are stable for up to 6 months at -20°C.

Other Notes

White, J.R., et al. 2000. J. Biol. Chem.275, 36626.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable


Certificates of Analysis (COA)

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