538916

16,16-Dimethyl Prostaglandin E2 - CAS 39746-25-3 - Calbiochem

A cell-permeable and orally available synthetic PGE2.

• Synonym(s): 16,16-Dimethyl Prostaglandin E2 - CAS 39746-25-3 - Calbiochem
• Empirical Formula (Hill Notation): C₂₂H₃₆O₅
• CAS Number: 39746-25-3
• Molecular Weight: 380.52
• MDL number: MFCD00151141
• UNSPSC Code: 12352200

Properties

• assay: ≥95% (HPLC)
• form: liquid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze; protect from light
• solubility: DMSO: 100 mg/mL; ethanol: 100 mg/mL; PBS, pH 7.2: 5 mg/mL
• shipped in: wet ice
• storage temp.: −70°C
• InChI: 1S/C22H36O5/c1-4-5-14-22(2,3)20(25)13-12-17-16(18(23)15-19(17)24)10-8-6-7-9-11-21(26)27/h6,8,12-13,16-17,19-20,24-25H,4-5,7,9-11,14-15H2,1-3H3,(H,26,27)/b8-6+,13-12+/t16-,17?,19-,20+/m0/s1
• InChI key: QAOBBBBDJSWHMU-BKSAQPBESA-N

Description

General description

A cell-permeable and orally available synthetic PGE2.

A cell-permeable and orally available synthetic PGE₂ (Cat. No. 538904) 16,16-dimethyl derivative that exhibits similar biological activity as PGE₂ as an EP receptor agonist both in in vitro and in in vivo, while being more resistant to PGDH metabolism. Shown to amplify wnt activity through cAMP/PKA-mediated regulation of cellular β-catenin protein stability during vertebrate development and organ regeneration.

A cell-permeable and orally available synthetic PGE₂ (Cat. No. 538904) 16,16-dimethyl derivative that exhibits similar biological activity as PGE₂ as an EP receptor agonist both in in vitro and in in vivo, while being more resistant to PGDH metabolism. Shown to amplify wnt activity through cAMP/PKA-mediated regulation of cellular β-catenin protein stability during vertebrate development and organ regeneration.

Warning

Toxicity: Flammable (J)

Physical form

Supplied as a solution in methylacetate (1 mg/100 µL)

Preparation Note

Gently blow away methylacetate under a stream of N2 and solubilize in either DMSO or EtOH purged with an inert gas.

Reconstitution

Following reconstitution in DMSO or EtOH store at ≤-70°C for up to 6 months; Store aqueous solutions on ice and use within 12 hrs.

Other Notes

Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.

Goessling, W., et al. 2009. Cell136, 1136.
Fitzgerald, J., et al. 2000. Endocrinology141, 291.
Coleman, R.A., et al. 1994. Pharmacol. Rev.46, 205.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• pictograms: GHS02,GHS07
• signalword: Danger
• hcodes: H225,H319,H336
• pcodes: P210 - P233 - P240 - P241 - P242 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Flam. Liq. 2 - STOT SE 3
• target_organs: Central nervous system
• supp_hazards: EUH066
• Storage Class: 3 - Flammable liquids
• wgk_germany: WGK 2
• flash_point_f: 3.2 °F - closed cup
• flash_point_c: -16 °C - closed cup