528113

PI 3-Kβ Inhibitor VI, TGX-221 - CAS 663619-89-4 - Calbiochem

The PI 3-Kβ Inhibitor VI, TGX-221, also referenced under CAS 663619-89-4, controls the biological activity of PI 3-Kβ. This small molecule/inhibitor is primarily used for Cell Signaling applications.

• Synonym(s): PI 3-Kβ Inhibitor VI, TGX-221 - CAS 663619-89-4 - Calbiochem, (±)-7-Methyl-2-(morpholin-4-yl)-9-(1-phenylaminoethyl)-pyrido[1,2-a]-pyrimidin-4-one, PI 3-K Inhibitor VI
• Empirical Formula (Hill Notation): C₂₁H₂₄N₄O₂
• CAS Number: 663619-89-4
• Molecular Weight: 364.44
• UNSPSC Code: 12352200

Properties

• Quality Level: 100
• assay: ≥97% (HPLC)
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze; protect from light
• color: white
• solubility: DMSO: 10 mg/mL; ethanol: 5 mg/mL
• shipped in: ambient
• storage temp.: 2-8°C

Description

General description

A cell-permeable morpholino-pyrimidinone compound that acts as a reversible, ATP-competitive, selective, and highly potent inhibitor of PI 3-Kβ (IC₅₀ = 0.005, 0.1, 5, and ≥3.5 µM for -β, -δ, -α and -γ isoforms, respectively) with little activity against a panel of 15 commonly studied protein kinases even at concentrations as high as 10.0 µM. An excellent tool for studying p110β-dependent responses both in cells in vitro and in animals in vivo.

Biochem/physiol Actions

Cell permeable: yes

Primary Target
PI 3-Kβ

Product competes with ATP.

Reversible: yes

Target IC₅₀: 0.005, 0.1, 5, and ≥3.5 µM for -β, -δ, -α and -γ isoforms, respectively

Packaging

Packaged under inert gas

Warning

Toxicity: Standard Handling (A)

Other Notes

Chaussade, C., et al. 2007. Biochem. J.404, 449.
Cosemans, J.M, et al. 2006. Blood108, 3045.
Condliffe, A.M., et al. 2005. Blood106, 1432.
Jackson, S.P., et al. 2005. Nat. Med.11, 507.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 2
• flash_point_f: Not applicable
• flash_point_c: Not applicable