5.08573

PPACK II, 2TFA

InSolution, ≥95%, Potent and specific irreversible inhibitor of plasma and glandular kallikreins

• Synonym(s): InSolution PPACK II, 2TFA, D-Phenylalanyl-L-phenylalanyl-L-arginine chloromethyl ketone, 2TFA, H-D-Phe-Phe-Arg-chloromethylketone, 2TFA, PPACK II, Trifluoroacetate Salt, PPACK II, Trifluoroacetate Salt InSolution, D-Phenylalanyl-L-prolyl-L-arginine chloromethyl ketone, 2TFA, H-D-Phe-Phe-Arg-chloromethylketone, 2TFA
• Empirical Formula (Hill Notation): C₂₅H₃₃ClN₆O₃ · 2C₂HF₃O₂
• CAS Number: 649748-23-2
• Molecular Weight: 729.07
• UNSPSC Code: 12352202
• NACRES: NA.77

Properties

• Quality Level: 100
• assay: ≥95% (HPLC)
• form: liquid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze; avoid repeated freeze/thaw cycles; protect from light
• storage temp.: −70°C

Description

General description

Potent and specific irreversible inhibitor of plasma and glandular kallikreins. Inhibits the cleavage of atrial naturiuretic peptide (ANP 1-126) by kallikreins. Also inhibits adrenal kininogenase, a kallikrein-like enzyme.

Biochem/physiol Actions

Primary Target
thrombin

Reversible: no

Secondary Target
plasma and glandular kallikreins

Packaging

Packaged under inert gas

Warning

Toxicity: Regulatory Review (Z)

Sequence

H-D-Phe-Phe-Arg-chloromethylketone, 2TFA

Physical form

A 10 mM (5 mg/686 µl) sterile-filtered solution of PPACK II, 2TFA (Cat. No. 520219) in H₂O.

Reconstitution

Following initial thaw, aliquot and freeze (-20°C). Aliquots are stable for up to 6 months at -20°C.

Other Notes

Byrne, R.E., and Scanu, A.M. 1989. J. Lipid Res.30, 109.
Scicli, G., et al. 1989. Adv. Exp. Med. Biol.247B, 217.
Gibson, T.R., et al. 1987. Endocrinology120, 764.
Kettner, G., and Shaw, E. 1981. Methods Enzymol.80, 826.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Storage Class: 12 - Non Combustible Liquids
• wgk_germany: WGK 1
• flash_point_f: Not applicable
• flash_point_c: Not applicable