5.08507

Isradipine

• Synonym(s): Isradipine, L-type voltage-gated Ca2+ channel blocker, Isradipine, PN 200-110
• Empirical Formula (Hill Notation): C₁₉H₂₁N₃O₅
• CAS Number: 75695-93-1
• Molecular Weight: 371.39
• MDL number: MFCD00153820
• UNSPSC Code: 12352200
• NACRES: NA.77

Properties

• assay: ≥98% (HPLC)
• Quality Level: 100
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze; protect from light
• color: yellow
• solubility: DMSO: 100 mM; ethanol: 50 mM
• storage temp.: 2-8°C
• InChI: 1S/C19H21N3O5/c1-9(2)26-19(24)15-11(4)20-10(3)14(18(23)25-5)16(15)12-7-6-8-13-17(12)22-27-21-13/h6-9,16,20H,1-5H3
• InChI key: HMJIYCCIJYRONP-UHFFFAOYSA-N

Description

General description

A water soluble voltage gated calcium channel gating inhibitor of the dihydropyridine class. In human ion channels, Isradipine has gating inhibition on Cav1.4 channels (1x10E-6 M) and Cav1.3 (3x10E-8) and in mouse ion channels a pIC₅₀ of 6.7. Often prescribed for hypertension (trade names DynaCirc, Prescal), recent animal models suggest a use in Parkinson′s Disease.

A water soluble voltage gated calcium channel gating inhibitor of the dihydropyridine class. In human ion channels, Isradipine has gating inhibition on Cav1.4 channels (1x10E-6 M) and Cav1.3 (3x10E-8) and in mouse ion channels a pIC₅₀ of 6.7. Often prescribed for hypertension (trade names DynaCirc, Prescal), recent animal models suggest a use in Parkinson′s Disease.

Please note that the molecular weight for this compound is batch-specific due to variable water content.

Biochem/physiol Actions

Primary Target
CaV

Warning

Toxicity: Standard Handling (A)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Chan, C. S. et al. 2007. Nature.447, 1081.
Baumann, L. et al. 2004. Invest. Ophthalmol. Vis. Sci.45, 708.
Koschak, A. et al. 2003. J. Neurosci.23, 6041.
Koschak, A. et al. 2001. J. Biol Chem276, 22100.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable