5.08148

Nefazodone Hydrochloride

• Synonym(s): Nefazodone Hydrochloride, 5-HT _2A Serotonin Receptor Antagonist, Nefazodone, BMY-13754, MJ-13754-1, Serzone, 5-HT_2A Serotonin Receptor Antagonist, Nefazodone, BMY-13754, MJ-13754-1, Serzone
• Empirical Formula (Hill Notation): C₂₅H₃₂ClN₅O₂ · xHCl
• CAS Number: 82752-99-6
• Molecular Weight: 470.01 (free base basis)
• MDL number: MFCD00935760
• UNSPSC Code: 12352200
• NACRES: NA.77

Properties

• assay: ≥99% (HPLC)
• Quality Level: 100
• form: solid
• potency: 26 nM K_i
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze; protect from light
• color: white
• solubility: ethanol: 10 mM; DMSO: 25 mM
• storage temp.: 2-8°C
• InChI: 1S/C25H32ClN5O2.ClH/c1-2-24-27-31(25(32)30(24)18-19-33-23-10-4-3-5-11-23)13-7-12-28-14-16-29(17-15-28)22-9-6-8-21(26)20-22;/h3-6,8-11,20H,2,7,12-19H2,1H3;1H
• InChI key: DYCKFEBIOUQECE-UHFFFAOYSA-N

Description

General description

A potent 5-HT_2A receptor antagonist (K_d = 26 nM), with moderate affinity for the alpha1-adrenergic receptor (K_d = 48 nM) and 5-HT_1A receptor (K_d = 80 nM). Originally developed as a clinical antidepressant but discontinued in 2004, nefazodone (Serzone) still remains a specific inhibitor of certain serotonergic pathways. Nefazodone also has been reported to induce mitochondrial dysfuntion.

Warning

Toxicity: Standard Handling (A)

Other Notes

Kim, J.-A. et al. 2012. Toxicol. Lett.214, 175.
Cusack, B. et al. 1994. Psychopharmacol.114, 559.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable