5.08119

SB 399885 Hydrochloride

• Synonym(s): SB 399885 Hydrochloride, 5-HT₆ Receptor antagonist, SB 399885 Hydrochloride, SB-399885, SB399885
• Empirical Formula (Hill Notation): C₁₈H₂₁Cl₂N₃O₄S · xHCl
• CAS Number: 402713-80-8
• Molecular Weight: 446.35 (free base basis)
• UNSPSC Code: 12352200

Properties

• assay: ≥99% (HPLC)
• Quality Level: 100
• form: solid
• potency: 1 nM K_i
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze; protect from light
• color: white
• solubility: DMSO: 100 mM; water: 100 mM
• storage temp.: 2-8°C
• InChI: 1S/C18H21Cl2N3O4S.ClH/c1-26-17-4-3-13(11-16(17)23-7-5-21-6-8-23)28(24,25)22-15-10-12(19)9-14(20)18(15)27-2;/h3-4,9-11,21-22H,5-8H2,1-2H3;1H
• InChI key: RNKCEBCFUSXSQE-UHFFFAOYSA-N

Description

General description

A high affinity 5-HT₆ Receptor antagonist (pKi = 9.0). Good solubility (to 100 mM in water or DMSO), oral availability, and penetrant to blood brain barrier. Over 200-fold selective for 5-HT₆ receptors vs all receptors, ion channels and enzymes tested in Hirst et al. 2006 publication. Shows nootropic, antidepressant and axiolytic effects comparable to well-described drugs such as diazepam, and therefore has been proposed as novel treatment for schizoprenia and Alzheimer′s disease.

Biochem/physiol Actions

Primary Target
5-HT₆

Warning

Toxicity: Standard Handling (A)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Wesolowska, A. et al. 2007. Pharmacol Rep.59, 664.
Li, Z. et al. 2007. Brain Res.1134, 70.

Hirst, et al. 2006. Eur. J. Pharm.553, 109.
Routledge, C. et al. 2000. Br. J. Pharmacol.130, 1606.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable