5.04842

CGP 37849

• Synonym(s): CGP 37849, (E)-(±)-2-Amino-4-methyl-5-phosphono­-3-pentenoic acid
• Empirical Formula (Hill Notation): C₆H₁₂NO₅P
• CAS Number: 127910-31-0
• Molecular Weight: 209.14
• MDL number: MFCD00153906
• UNSPSC Code: 12352200
• NACRES: NA.77

Properties

• assay: ≥99% (HPLC)
• Quality Level: 100
• form: solid
• potency: 35 nM K_i
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze; protect from light
• color: white
• solubility: H₂O: 100 mM
• storage temp.: 2-8°C
• SMILES string: [P](=O)(O)(O)C\C(=C\C(N)C(=O)O)\C
• InChI: 1S/C6H12NO5P/c1-4(3-13(10,11)12)2-5(7)6(8)9/h2,5H,3,7H2,1H3,(H,8,9)(H2,10,11,12)/b4-2+
• InChI key: BDYHNCZIGYIOGJ-DUXPYHPUSA-N

Description

General description

A highly potent competitive antagonist selective for NMDA receptors (K_i = 35 nM). Biologically viable admitted orally or systematically. Widely used in studies of epilepsy, schizophrenia, depression, stress and anxiety related mental disorders.

Biochem/physiol Actions

Primary Target
NMDA receptors

Warning

Toxicity: Standard Handling (A)

Preparation Note

Slight warming is required for complete solubilization.

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Serafini, G., et al. 2013. Curr. Pharmaceut. Design19, 1898.
Szewczyk, B., et al. 2012. Expert. Op. Invest. Drugs21, 91.
Przegalinski, E., et al. 2000. Neuropharmacol.39, 1858.
Maj, J., et al. 1993. Polish J. Pharmacol.45, 455.
Fagg, E., et al. 1990. Br. J. Pharmacol.99, 791.
Schmutz, M., et al. 1990. Naunyn-Schmiedebergʹs Arch. Pharmacol.342, 61.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable