5.04519

CIQ

• Synonym(s): CIQ, (3-Chlorophenyl) [3,4-dihydro-6,7-dimethoxy-1-[(4-methoxyphenoxy)methyl]-2(1H)-isoquinolinyl]methanone
• Empirical Formula (Hill Notation): C₂₆H₂₆ClNO₅
• CAS Number: 486427-17-2
• Molecular Weight: 467.94
• UNSPSC Code: 12352200

Properties

• assay: ≥98% (HPLC)
• Quality Level: 100
• form: powder
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze; protect from light
• color: white
• solubility: DMSO: 10 mg/mL
• storage temp.: 2-8°C
• InChI: 1S/C26H26ClNO5/c1-30-20-7-9-21(10-8-20)33-16-23-22-15-25(32-3)24(31-2)14-17(22)11-12-28(23)26(29)18-5-4-6-19(27)13-18/h4-10,13-15,23H,11-12,16H2,1-3H3
• InChI key: VYMILMYEENZHAR-UHFFFAOYSA-N

Description

General description

A positive allosteric modulator selective for NR2C/D containing NMDA receptors (EC₅₀ = 2.7 and 2.8 µM for NR2C and NR2D, respectively). Increases channel opening frequency of recombinant NR2C/D containing NMDA receptors by two-fold without altering mean open time or EC50 values for glutamate or glycine bindings. No effect on NR2A or NR2B subtypes.

Biochem/physiol Actions

Primary Target
NMDA receptors

Warning

Toxicity: Standard Handling (A)

Preparation Note

Slight warming is required for complete solubilization.

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Mullasseril, P., et al. 2010. Nat. Commun.1, 1038.
Ogden, K., et al. 2013. Mol. Pharmacol.83, 1045.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable