488230

Nogo-66 (1-40) Antagonist Peptide, Synthetic - Calbiochem

• Synonym(s): Nogo-66 (1-40) Antagonist Peptide, Synthetic - Calbiochem, Nogo Extracellular Peptide, 1-40, NEP1-40, Ac-RIYKGVIQAIQKSDEGHPFRAYLESEVAISEELVQKYSNS-NH₂
• Empirical Formula (Hill Notation): C₂₀₆H₃₂₄N₅₆O₆₅
• Molecular Weight: 4625.11
• UNSPSC Code: 12352200

Properties

• assay: ≥95% (HPLC)
• Quality Level: 100
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze; desiccated (hygroscopic); protect from light
• color: white
• solubility: DMSO: 5 mg/mL
• shipped in: wet ice
• storage temp.: −20°C

Description

General description

This product has been discontinued.

An end-protected 40-mer peptide derived from the N-terminal fragment of the Nogo-66 domain that acts as a selective, competitive, high affinity antagonist of Nogo-66 receptor (NgR). Although NgR serves as the common receptor for both Nogo-66 and MAG (myelin-associated glycoprotein), NEP1-40 blocks only the inhibition of neurite outgrowth induced by Nogo-66, but not that by MAG. Promotes axonal regeneration after spinal cord injury in rats.

An end-protected 40 amino acid peptide derived from the N-terminal fragment of the Nogo-66 domain that is normally expressed on the surface of oligodendrocytes. Acts as a selective, competitive, high affinity antagonist of Nogo-66 receptor (NgR). Although NgR serves as the common receptor for both Nogo-66 and myelin-associated glycoprotein (MAG), NEP1-40 blocks the inhibition of Nogo-66-induced neurite outgrowth, but not that of MAG. Promotes axonal regeneration following spinal cord injury in rats.

Biochem/physiol Actions

Cell permeable: no

Primary Target
Nogo-66 receptor (NgR)

Product competes with ATP.

Reversible: no

Packaging

Packaged under inert gas

Warning

Toxicity: Standard Handling (A)

Sequence

Ac-Arg-Ile-Tyr-Lys-Gly-Val-Ile-Gln-Ala-Ile-Gln-Lys-Ser-Asp-Glu-Gly-His-Pro-Phe-Arg-Ala-Tyr-Leu-Glu-Ser-Glu-Val-Ala-Ile-Ser-Glu-Glu-Leu-Val-Gln-Lys-Tyr-Ser-Asn-Ser-NH₂

Physical form

Supplied as a trifluoroacetate salt.

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

GrandPré, T., et al. 2002. Nature417, 547.
Liu, B.P., et al. 2002. Science297, 1190.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 1
• flash_point_f: Not applicable
• flash_point_c: Not applicable