487955

NOC-12

A nitric oxide (NO) donor similar to NOC-5 and NOC-7 but with a much longer half-life of NO release.

• Synonym(s): NOC-12, N-Ethyl-2-(1-ethyl-2-hydroxy-2-nitrosohydrazino)ethanamine
• Empirical Formula (Hill Notation): C₆H₁₆N₄O₂
• CAS Number: 146724-89-2
• Molecular Weight: 176.22
• MDL number: MFCD00674898
• UNSPSC Code: 12352200

Properties

• Quality Level: 100
• assay: ≥90% (HPLC)
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze; desiccated (hygroscopic); protect from light
• color: white
• solubility: 0.1 M NaOH: soluble; water: soluble
• shipped in: ambient
• storage temp.: −20°C
• InChI: 1S/C6H16N4O2/c1-3-7-5-6-9(4-2)10(12)8-11/h7,11H,3-6H2,1-2H3/b10-8-
• InChI key: DPKCLDSTXVCYSN-NTMALXAHSA-N

Description

General description

A nitric oxide (NO) donor similar to NOC-5 (Cat. No. 487950) and NOC-7 (Cat. No. 487952) but with a much longer half-life of NO release. Half-life (t_½) in PBS, pH 7.4 is 327 minutes at 22°C. Inhibits the proliferation of arterial smooth muscle cells in a dose-dependent manner. Relatively stable in alkaline solution (pH ≥10.0).

Biochem/physiol Actions

Cell permeable: no

Product does not compete with ATP.

Reversible: no

Warning

Toxicity: Irritant (B)

Other Notes

Ambalavanan, N., et al. 1999. Biol. Neonate76, 291.
Hrabie, J.A., et al. 1993. J. Org. Chem.58, 1472.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• pictograms: GHS02
• signalword: Danger
• hcodes: H242
• pcodes: P210 - P234 - P235 - P240 - P370 + P378 - P403
• Hazard Classifications: Self-react. C
• Storage Class: 5.2 - Organic peroxides and self-reacting hazardous materials
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable