371543

Guanosine 5′-O-(2-Thiodiphosphate), Trilithium Salt

Non-hydrolyzable GDP analog that competitively inhibits G-protein activation by GTP and GTP analogs. Stimulates adenylate cyclase activity in sarcolemmal membranes by inactivating Gi proteins.

• Synonym(s): Guanosine 5′-O-(2-Thiodiphosphate), Trilithium Salt, GDP-β-S, 3Li
• Empirical Formula (Hill Notation): C₁₀H₁₂N₅O₁₀P₂S · 3Li
• CAS Number: 97952-36-8
• Molecular Weight: 477.07
• MDL number: MFCD00057735
• UNSPSC Code: 12352208

Properties

• Quality Level: 100
• assay: ≥85% (HPLC)
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze; desiccated (hygroscopic)
• color: white
• solubility: water: 50 mg/mL
• shipped in: ambient
• storage temp.: −20°C
• InChI: 1S/C10H15N5O10P2S.3Li/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(24-9)1-23-26(19,20)25-27(21,22)28;;;/h2-3,5-6,9,16-17H,1H2,(H,19,20)(H2,21,22,28)(H3,11,13,14,18);;;/q;3*+1/p-3/t3-,5-,6-,9-;;;/m1.../s1
• InChI key: LMCWQGPJYZRMKU-CYCLDIHTSA-K

Description

General description

A nonhydrolyzable GDP analog that competitively inhibits G-protein activation by GTP and GTP analogs.

Non-hydrolyzable GDP analog that competitively inhibits G-protein activation by GTP and GTP analogs. Stimulates adenylate cyclase activity in sarcolemmal membranes by inactivating G_i proteins.

Warning

Toxicity: Standard Handling (A)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions lose 5% of their activity after 6 months at -20°C.

Other Notes

Piacentini, L., et al. 1996. Biochim. Biophys. Acta1282, 11.
Eberhard, D.A. and Holz, R.W., et al. 1991. Biochem J.279, 447.
Silk, S.T., et al. 1989. J. Biol. Chem.264, 21466.
Burch, R.M., et al. 1987. Proc. Natl. Acad. Sci. USA84, 6374.
Gilman, A.G. 1987. Annu. Rev. Biochem.56, 615.
Eckstein, F., et al. 1979. J. Biol. Chem.254, 9829.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable