361541
GSK-3β Inhibitor II - CAS 478482-75-6 - Calbiochem
The GSK-3β Inhibitor II, also referenced under CAS 478482-75-6, controls the biological activity of GSK-3β. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
Synonym(s):
GSK-3β Inhibitor II - CAS 478482-75-6 - Calbiochem, Glycogen Synthase Kinase-3β Inhibitor II, 2-Thio(3-iodobenzyl)-5-(1-pyridyl)-[1,3,4]-oxadiazole
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About This Item
Empirical Formula (Hill Notation):
C14H10IN3OS
CAS Number:
Molecular Weight:
395.22
UNSPSC Code:
12352200
Quality Level
assay
≥95% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
protect from light
color
yellow
solubility
DMSO: 10 mg/mL
shipped in
wet ice
storage temp.
−20°C
General description
A 2-thio-[1,3,4]-oxadiazole-pyridyl derivative that acts as a potent inhibitor of glycogen synthase kinase-3β (IC50 = 390 nM).
A 2-thio-[1,3,4]-oxadiazole-pyridyl derivative that acts as a potent inhibitor of glycogen synthase kinase-3b (IC50 = 390 nM).
Biochem/physiol Actions
Cell permeable: no
Primary Target
Gsk-3β
Gsk-3β
Product does not compete with ATP.
Reversible: no
Target IC50: 390 nM against glycogen synthase kinase-3β
Packaging
Packaged under inert gas
Warning
Toxicity: Standard Handling (A)
Reconstitution
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Other Notes
Naerum, L., et al. 2002. Bioorg. Med. Chem. Lett.12, 1525.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Storage Class
10-13 - German Storage Class 10 to 13
Certificates of Analysis (COA)
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Lars Naerum et al.
Bioorganic & medicinal chemistry letters, 12(11), 1525-1528 (2002-05-29)
Using a virtual screening strategy based on a methodology derived from the CATS molecular descriptor, a novel compound class with inhibitory activity against the GSK-3 enzyme was identified through scaffold hopping. These compounds were readily synthesized, either by solid-phase or
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