360512

Glycocholic Acid, Sodium Salt

Formed by the conjugation of cholic acid with glycine. Aggregation number: 2.1.

• Synonym(s): Glycocholic Acid, Sodium Salt, GAS, Sodium cholylglycinate
• CAS Number: 863-57-0
• UNSPSC Code: 12352106
• NACRES: NA.21

Properties

• Quality Level: 100
• assay: 100.1% dry basis (titration)
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze
• aggregation number: 2.1
• color: white to off-white
• pKa: 3.8
• CMC: 7.1 mM
• solubility: water: 200 mg/mL; ethanol: soluble
• shipped in: ambient
• storage temp.: 15-25°C
• InChI: 1S/C26H43NO6.Na/c1-14(4-7-22(31)27-13-23(32)33)17-5-6-18-24-19(12-21(30)26(17,18)3)25(2)9-8-16(28)10-15(25)11-20(24)29;/h14-21,24,28-30H,4-13H2,1-3H3,(H,27,31)(H,32,33);/q;+1/p-1
• InChI key: OABYVIYXWMZFFJ-UHFFFAOYSA-M

Description

General description

Formed by the conjugation of cholic acid with glycine. Aggregation number: 2.1.

Glycocholic acid (GCA) is a crystalline secondary bile acid. It is a conjugate of cholic acid and glycine. The microbiota produces GCA in the small intestine by the catalysis of enzymes. Glycocholic Acid, Sodium Salt, an anionic surfactant with a steroidal backbone is soluble in water.Formed by the conjugation of cholic acid with glycine (aggregation number: 2.1; CMC: 7.1 mM; pK_a: 3.8).

Application

Glycocholic Acid, Sodium Salt- is suitable for use:

• as a component in the sodium phosphate/NaCl (phosphate buffer saline-PBS) buffer to prepare protein samples
• in the preparation of fluorescently labeled mixed micelles to investigate the uptake by and transport through Caco-2 cells of two mixed micelle formulations of vitamin K
• to prepare mixed micelle solutions to encapsulate a lipid-soluble drug (vitamin K₁) to analyze its influence on the quality and stability of the mixed micelle systems

Biochem/physiol Actions

Glycocholic acid (GCA) is involved in the emulsification of fats. Glycocholic acid sodium (GAS) salt is one of the important cholic acid salts in the pharmaceutical industry used to prepare mixed micelles (MMs).

Warning

Toxicity: Standard Handling (A)

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable