344280

Fostriecin, Sodium Salt, Streptomyces pulveraceous - CAS 87860-39-7 - Calbiochem

An antitumor antibiotic that acts as a potent protein phosphatase 2A (PP2A) inhibitor (IC₅₀ = 3.2 nM).

• Synonym(s): Fostriecin, Sodium Salt, Streptomyces pulveraceous - CAS 87860-39-7 - Calbiochem, FST, Phosphotrienin
• Empirical Formula (Hill Notation): C₁₉H₂₆NaO₉P
• CAS Number: 87860-39-7
• Molecular Weight: 452.37
• MDL number: MFCD09971059
• UNSPSC Code: 12352200

Properties

• Quality Level: 100
• assay: ≥98% (HPLC)
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze; desiccated (hygroscopic); protect from light
• color: colorless
• solubility: ethanol: 10 mg/mL; methanol: 10 mg/mL; water: 50 mg/mL
• shipped in: ambient
• storage temp.: −20°C

Description

General description

An antitumor antibiotic that acts as a potent protein phosphatase 2A (PP2A) inhibitor (IC₅₀ = 3.2 nM). Inhibits protein phosphatase 1 (PP1) at much higher concentrations (IC₅₀ = 131 µM). Does not affect the activity of protein phosphatase 2B (PP2B). Inhibits the catalytic activity of DNA topoisomerase II (topo II) and arrests cell growth at the G₂/M phase of the cell cycle in a dose-dependent manner.

Antitumor antibiotic that acts as a potent protein phosphatase 2A (PP2A) inhibitor (IC₅₀ = 3.2 nM). Also inhibits protein phosphatase 1 (PP1) at higher concentrations (IC₅₀ = 131 µM), but has no effect on protein phosphatase 2B (PP2B). Inhibits the catalytic activity of DNA topoisomerase II (topo II) and arrests cell growth at the G2/M phase of the cell cycle in a dose-dependent manner.

Biochem/physiol Actions

Cell permeable: no

Primary Target
PP2a

Product does not compete with ATP.

Reversible: no

Target IC₅₀: 3.2 nM, 131 µM, against protein phosphatase 2A (PP2A), protein phosphatase 1 (PP1), respectively

Packaging

Packaged under inert gas

Warning

Toxicity: Standard Handling (A)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 months at -20°C.

Other Notes

Cheng, A., et al. 1998. Cancer Res. 58, 3611.
Walsh, A.H., et al. 1997. FEBS Lett. 416, 230.
Boritzki, T.J., et al. 1988. Biochem. Pharmacol. 37, 4063.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable