344101

FSB

A fluorine analog of the amyloidophilic fluorescent probe BSB that crosses the blood-brain barrier and displays low toxicity.

• Synonym(s): FSB, (E,E)-1-Fluoro-2,5- bis(3-hydroxycarbonyl-4-hydroxy)styrylbenzene
• Empirical Formula (Hill Notation): C₂₄H₁₇FO₆
• CAS Number: 760988-03-2
• Molecular Weight: 420.39
• UNSPSC Code: 41105331
• NACRES: NA.25

Properties

• Quality Level: 100
• assay: ≥95% (HPLC)
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze; protect from light
• color: yellow
• solubility: DMSO: 200 mg/mL
• shipped in: ambient
• storage temp.: −20°C

Description

General description

A fluorine analog of the amyloidophilic fluorescent probe BSB (Cat. No. 286895) that crosses the blood-brain barrier and displays low toxicity (LD₅₀ >80 mg/kg). Suitable for non-invasive amyloid visualization in living transgenic Tg2576 mice by using ¹⁹F and ¹H-MRI (Magnetic Resonance Imaging). Also useful for staining plaques and neurofibrillary tangles in brain tissue sections of Alzheimer′s diseased patients with improved sensitivity, and reduced background.

This fluorine analog of the amyloidophilic fluorescent probe BSB (Cat. No. 286895) crosses the blood-brain barrier and displays low toxicity (LD₅₀ >80 mg/kg). Suitable for non-invasive amyloid visualization in living transgenic Tg2576 mice by using ¹⁹F and ¹H-MRI. Also useful for staining plaques and neurofibrillary tangles in brain tissue sections of Alzheimer′s diseased patients, with improved sensitivity and reduced background.

Biochem/physiol Actions

Cell permeable: no

Primary Target
Amyloidophilic fluorescent probe

Product does not compete with ATP.

Reversible: no

Packaging

Packaged under inert gas

Warning

Toxicity: Standard Handling (A)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Other Notes

Higuchi, M., et al. 2005. Nat. Neurosci.8, 527.
Sato, K., et al. 2004. Eur. J. Med. Chem.39, 573.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 1
• flash_point_f: Not applicable
• flash_point_c: Not applicable