The EGFR/ErbB-2 Inhibitor, also referenced under CAS 179248-61-4, controls the biological activity of EGFR/ErbB-2. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
A cell-permeable 4-anilino quinazoline compound that acts a potent, reversible, and ATP-competitive inhibitors of EGFR and c-erbB2 (IC50 = 20 nM and 79 nM, respectively), members of the type I growth factor receptor family that is involved in breast cancer development and progression. Shown to effectively inhibit the proliferation (IC50 = ~ 1.2-2.5 µM) of tumor cells overexpressing EGRF or c-erbB-2.
A cell-permeable, potent, reversible, and ATP-competitive inhibitor of the tyrosine kinase activity of EGFR (IC50 = 20 nM) and c-erbB2 (IC50 = 79 nM), members of the type I growth factor receptor family implicated in the development and progression of various forms of cancer, including breast and small lung cell carcinoma. Shown to effectively inhibit the proliferation (IC50 ~1.2-2.5 µM) of tumor cells overexpressing EGRF or c-erbB-2.
Biochem/physiol Actions
Cell permeable: yes
Primary Target EGFR
Product competes with ATP.
Reversible: yes
Target IC50: 20 nM and 79 nM, against EGFR and c-erbB2, respectively
Packaging
Packaged under inert gas
Warning
Toxicity: Carcinogenic / Teratogenic (D)
Reconstitution
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Other Notes
Cockerill, S., et al. 2001. Bioorg. Med. Chem. Lett.11, 1401.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Storage Class
11 - Combustible Solids
wgk_germany
WGK 1
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
Already Own This Product?
Find documentation for the products that you have recently purchased in the Document Library.
Song control nuclei have distinct sexual differences in songbirds. However, the mechanism that underlies the sexual differentiation of song nuclei is still not well understood. Using a combination of anatomical, pharmacological, genetic, and behavioral approaches, the present study investigated the
Questions
Reviews
★★★★★ No rating value
Active Filters
Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.
