200485

Bestatin Methyl Ester - CAS 65322-89-6 - Calbiochem

• Synonym(s): Bestatin Methyl Ester - CAS 65322-89-6 - Calbiochem, (-)-N-[(2S, 3R)-3-Amino-2-hydroxy-4-phenylbutyryl]-L-leucine Methyl Ester
• Empirical Formula (Hill Notation): C₁₇H₂₆N₂O₄
• CAS Number: 65322-89-6
• Molecular Weight: 322.40
• UNSPSC Code: 12352200

Properties

• assay: ≥97% (TLC)
• Quality Level: 100
• form: semisolid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze
• color: yellowish
• solubility: DMSO: 100 mg/mL
• shipped in: ambient
• storage temp.: 2-8°C

Description

General description

This product has been discontinued.

A cell-permeable derivative of Bestatin (Cat. No. 200484) that displays slightly stronger inhibition of neutral aminopeptidase than Bestatin but has much weaker activity against basic aminopeptidase. Also augments Fas- or TNF-α-induced apoptosis in solid tumor cell lines.

A cell-permeable derivative of Bestatin (Cat. No. 200484) that displays stronger inhibition of neutral aminopeptidase than Bestatin (IC₅₀ = 31.6 nM). Exhibits weaker activity against basic aminopeptidase (IC₅₀ = 400.1 nM). Also reported to augment Fas- (IC₅₀ = 235.4 nM) or TNF-α-induced apoptosis in solid tumor cell lines.

Biochem/physiol Actions

Cell permeable: yes

Primary Target
Neutral amino pepsidase

Product does not compete with ATP.

Reversible: no

Target IC₅₀: 31.6 nM against neutral amino pepsidase

Packaging

Packaged under inert gas

Warning

Toxicity: Standard Handling (A)

Preparation Note

Unstable in aqueous solution; dilute just prior to use.

Reconstitution

Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.

Other Notes

Sekine, K., et al. 2001. Int. J. Cancer94, 485.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Storage Class: 10-13 - German Storage Class 10 to 13