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Amastatin, Streptomyces sp. - CAS 67655-94-1 - Calbiochem

Amastatin is a non-toxic inhibitor of aminopeptidase A (Ki = 1 µM) and leucine aminopeptidase.

Synonym(s):

Amastatin, Streptomyces sp. - CAS 67655-94-1 - Calbiochem, (2S,3R)-3-Amino-2-hydroxy-5-methylhexanoyl-Val-Val-Asp-OH

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About This Item

CAS Number:
67655-94-1
UNSPSC Code:
12352200

Quality Level

100

assay

≥97% (HPLC)

form

amorphous solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze

color

colorless

solubility

DMSO: 10 mg/mL

shipped in

ambient

storage temp.

10-30°C

InChI

1S/C21H38N4O8/c1-9(2)7-12(22)17(28)20(31)25-16(11(5)6)19(30)24-15(10(3)4)18(29)23-13(21(32)33)8-14(26)27/h9-13,15-17,28H,7-8,22H2,1-6H3,(H,23,29)(H,24,30)(H,25,31)(H,26,27)(H,32,33)/t12-,13+,15+,16+,17+/m1/s1

InChI key

QFAADIRHLBXJJS-ZAZJUGBXSA-N

General description

Non-toxic inhibitor of aminopeptidase A (Ki = 1 µM) and leucine aminopeptidase. Also acts as a slow-binding, competitive inhibitor of aminopeptidase M. Does not inhibit aminopeptidase B, chymotrypsin, elastase, papain, pepsin, thermolysin, or trypsin.
Non-toxic specific inhibitor of aminopeptidase A and leucine aminopeptidase. Also acts as a slow-binding, competitive inhibitor of aminopeptidase M. Does not inhibit aminopeptidase B, chymotrypsin, elastase, papain, pepsin, thermolysin, or trypsin.

Biochem/physiol Actions

Cell permeable: no
Primary Target
Aminopeptidase A
Product does not compete with ATP.
Reversible: no
Target Ki: 1 µM against aminopeptidase A

Warning

Toxicity: Standard Handling (A)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.

Other Notes

Rich, D.H., et al. 1984. J. Med. Chem. 27, 417.
Jobe, H., et al. 1979. Agric. Biol. Chem.43, 591.
Aoyagi, T., et al. 1978. J. Antibiot.31, 636.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

10-13 - German Storage Class 10 to 13

Certificates of Analysis (COA)

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