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1.11474

Millipore

1,4-Dithiothreitol

for biochemistry

Synonym(s):

1,4-Dithiothreitol, DTT, Cleland’s reagent

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About This Item

Linear Formula:
(C2H3OHSH)2
CAS Number:
3483-12-3
Molecular Weight:
154.25
MDL number:
MFCD00004877
UNSPSC Code:
12352104
EC Index Number:
222-468-7
NACRES:
NB.21

grade

for biochemistry

Quality Level

200

assay

≥99% (iodometric)

form

solid

potency

400 mg/kg LD50, oral (Rat)

reaction suitability

reagent type: reductant

pH

5.1 (20 °C, 10 g/L in H2O)

mp

40-43 °C

transition temp

flash point >110 °C

bulk density

300 kg/m3

storage temp.

2-8°C

InChI

1S/C4H10O2S2/c5-3(1-7)4(6)2-8/h3-8H,1-2H2/t3-,4-/m0/s1

InChI key

VHJLVAABSRFDPM-IMJSIDKUSA-N

Related Categories

Application


  • Drug delivery using reduction-responsive hydrogel based on carboxyethyl-succinoglycan with highly improved rheological, antibacterial, and antioxidant properties.: This study explores the application of 1,4-Dithiothreitol in developing reduction-responsive hydrogels, highlighting significant enhancements in rheological, antibacterial, and antioxidant characteristics, suitable for drug delivery systems (Kim et al., 2024).

  • Preparation and properties of hydrogel photonic crystals assembled by biodegradable nanogels.: Research discusses the integration of 1,4-Dithiothreitol in the assembly of hydrogel photonic crystals using biodegradable nanogels, emphasizing their potential in creating novel photonic materials (Zhang et al., 2024).

  • Optimized total RNA isolation from bovine sperm with enhanced sperm head lysis.: The paper highlights the use of 1,4-Dithiothreitol in optimizing RNA isolation techniques from bovine sperm, which enhances sperm head lysis, crucial for reproductive biology studies (Tiwari et al., 2024).

  • Preparation of a Convertible Spacer Containing a Disulfide Group for Versatile Functionalization of Oligonucleotides.: Discusses the synthesis of a convertible spacer containing a disulfide group using 1,4-Dithiothreitol, enabling versatile functionalization of oligonucleotides for therapeutic and diagnostic applications (Pontarelli et al., 2023).

Analysis Note

Assay (iodometric): ≥ 99 %
Identity (IR-spectrum): passes test
Melting point: 40 - 43 °C
Heavy metals (as Pb): ≤ 10 ppm
Fe (Iron): ≤ 5 ppm

pictograms

CorrosionExclamation mark
GHS05,GHS07

signalword

Danger

Hazard Classifications

Acute Tox. 4 Oral - Eye Dam. 1 - Skin Irrit. 2

Storage Class

11 - Combustible Solids

wgk_germany

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

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