1.06446

tri-Sodium citrate dihydrate

powder, EMPROVE^® ESSENTIAL, Ph. Eur., BP, JP, USP, E 331

• Synonym(s): Sodium citrate tribasic dihydrate, Trisodium Citrate, Sodium Citrate, Dihydrate, Citric acid trisodium salt dihydrate, Trisodium citrate dihydrate
• Linear Formula: HOC(COONa)(CH₂COONa)₂ · 2H₂O
• CAS Number: 6132-04-3
• Molecular Weight: 294.10
• Beilstein/REAXYS Number: 6104939
• MDL number: MFCD00150031
• UNSPSC Code: 12352107
• E Number: E331
• EC Index Number: 200-675-3

Properties

• agency: BP; JP; Ph. Eur.; USP
• Quality Level: 500
• product line: EMPROVE^® ESSENTIAL
• form: powder; solid
• pH: 7.5-9.0 (25 °C, 50 g/L in H₂O)
• mp: 150 °C (anhydrous substance); >300 °C (lit.)
• application(s): liquid formulation; ophthalmics; pharmaceutical; semi-solid formulation; solid formulation
• storage temp.: 2-30°C
• SMILES string: O.O.[Na+].[Na+].[Na+].OC(CC([O-])=O)(CC([O-])=O)C([O-])=O
• InChI: 1S/C6H8O7.3Na.2H2O/c7-3(8)1-6(13,5(11)12)2-4(9)10;;;;;/h13H,1-2H2,(H,7,8)(H,9,10)(H,11,12);;;;2*1H2/q;3*+1;;/p-3
• InChI key: NLJMYIDDQXHKNR-UHFFFAOYSA-K

Description

General description

Finding the right excipient that matches your needs as well as regulatory demands can be a complicated challenge. With our application know-how and regulatory expertise, we support you in every step of development, scale-up, and production.
As part of our Emprove^® Program, our raw materials are offered with extensive documentation facilitating compliance of your pharma and biopharma product, full supply chain transparency and risk mitigation. Our SAFC^® portfolio of high-quality products for biopharmaceutical and pharmaceutical formulation and production withstands strict quality control procedures and is produced according to applicable cGMP guidelines.

application

tri-Sodium citrate dihydrate is typically used as a citrate buffer system component for biomolecule downstream chromatography steps or final liquid formulation.

Legal Information

Emprove is a registered trademark of Merck KGaA, Darmstadt, Germany

SAFC is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 1
• flash_point_f: Not applicable
• flash_point_c: Not applicable