1.00635

Salicylic acid

fine powder EMPROVE^® ESSENTIAL Ph Eur,BP,USP

• Synonym(s): Salicylic acid, 2-Hydroxybenzoic acid
• Empirical Formula (Hill Notation): C₇H₆O₃
• CAS Number: 69-72-7
• Molecular Weight: 138.12
• MDL number: MFCD00002439
• UNSPSC Code: 12352106
• EC Index Number: 200-712-3

Properties

• agency: BP; Ph. Eur.; USP
• Quality Level: 500
• vapor pressure: <1 hPa ( 100 °C)
• product line: EMPROVE^® ESSENTIAL
• assay: 98.0-102.0% dry basis (HPLC)
• form: solid
• autoignition temp.: 500 °C
• potency: 1250-1580 mg/kg LD₅₀, oral (Rat); >2000 mg/kg LD₅₀, skin (Rat)
• technique(s): tissue culture: suitable
• pH: 2.4 ( in H₂O, saturated solution)
• bp: 211 °C/1013 hPa
• mp: 157-159 °C
• transition temp: flash point 157 °C
• solubility: water: 2 g/L at 20 °C
• density: 1.443 g/cm³ at 20 °C
• bulk density: 400‑500 kg/m³
• anion traces: chloride (Cl^-): ≤0.0100%; sulfate (SO₄^2-): ≤0.0200%
• application(s): liquid formulation; pharmaceutical
• storage temp.: 15-25°C
• InChI: 1S/C7H6O3/c8-6-4-2-1-3-5(6)7(9)10/h1-4,8H,(H,9,10)
• InChI key: YGSDEFSMJLZEOE-UHFFFAOYSA-N

Description

General description

We offer a range of high quality critical raw materials, solvents and reagents plus the documentation and expertise to meet stringent regulatory requirements. In addition to our comprehensive portfolio, we also offer custom manufacturing services to meet your exact needs. As part of our Emprove^® Program, our raw materials are offered with extensive documentation facilitating compliance of your pharma and biopharma product, full supply chain transparency and risk mitigation. Our SAFC^® portfolio of high-quality products for biopharmaceutical and pharmaceutical formulation and production withstands strict quality control procedures and is produced according to applicable cGMP guidelines.

Application

Salicylic acid is used in dermatological medicine for skin exfoliating and acne. Salicylic acid Emprove^® Essential is suitable for pharmaceutical applications.

Legal Information

Emprove is a registered trademark of Merck KGaA, Darmstadt, Germany

SAFC is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• pictograms: GHS08,GHS05,GHS07
• signalword: Danger
• hcodes: H302,H318,H361d
• pcodes: P202 - P264 - P280 - P301 + P312 - P305 + P351 + P338 - P308 + P313
• Hazard Classifications: Acute Tox. 4 Oral - Eye Dam. 1 - Repr. 2
• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 1
• flash_point_f: 314.6 °F - closed cup
• flash_point_c: 157 °C - closed cup