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09-101

Sigma-Aldrich

Anti-cGMP (cyclic GMP) Antibody

serum, Upstate®

Synonym(s):

Guanosine 3′, 5′-cyclic monophosphate

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About This Item

UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

biological source

rabbit

Quality Level

100

antibody form

serum

antibody product type

primary antibodies

clone

polyclonal

species reactivity (predicted by homology)

all

manufacturer/tradename

Upstate®

technique(s)

ELISA: suitable
immunohistochemistry: suitable
radioimmunoassay: suitable

isotype

IgG

NCBI accession no.

NM_001098512.1
NM_006258.2

UniProt accession no.

Q13976

shipped in

wet ice

target post-translational modification

unmodified

Gene Information

human ... PRKG1(5592)

Specificity

Recognizes cGMP. Very little cross reactivity to cAMP based on ELISA.

Immunogen

2 Monosuccinyl cyclic GMP conjugated to KLH

application

Anti-cGMP (cyclic GMP) Antibody detects level of cGMP (cyclic GMP) & has been published & validated for use in ELISA, IH, RIA.
Research Category
Signaling
Research Sub Category
GPCR, cAMP/cGMP & Calcium Signaling

Quality

Routinely evaluated by ELISA

Physical form

Serum

Storage and Stability

2 years at -20°C from date of shipment

Legal Information

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

10 - Combustible liquids

wgk_germany

WGK 1

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Chongyang Zhang et al.
Journal of the American Heart Association, 11(2), e023053-e023053 (2022-01-06)
Background cGMP-hydrolyzing phosphodiesterase type 5 (PDE5) regulates vascular smooth muscle cell (SMC) contraction by antagonizing cGMP-dependent protein kinase I (PKGI)-dependent SMC relaxation. SMC contractile dysfunction is implicated in the pathogenesis of aortic aneurysm. PDE5 inhibitors have been used for treating
Susanne Vogeler et al.
BMC developmental biology, 20(1), 23-23 (2020-11-25)
Nitric oxide (NO) is presumed to be a regulator of metamorphosis in many invertebrate species, and although NO pathways have been comparatively well-investigated in gastropods, annelids and crustaceans, there has been very limited research on the effects of NO on

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