N-090

Nortriptyline-D₃ hydrochloride solution

1.0 mg/mL in methanol (as free base), ampule of 1 mL, certified reference material, Cerilliant^®

• Empirical Formula (Hill Notation): C₁₉D₃H₁₈N · HCl
• CAS Number: 136765-48-5
• Molecular Weight: 302.86
• MDL number: MFCD00198172
• UNSPSC Code: 41116107
• PubChem Substance ID: 329818468
• NACRES: NA.24

Properties

• grade: certified reference material
• form: liquid
• feature: (Snap-N-Spike^®)
• packaging: ampule of 1 mL
• manufacturer/tradename: Cerilliant^®
• concentration: 1.0 mg/mL in methanol (as free base)
• technique(s): gas chromatography (GC): suitable; liquid chromatography (LC): suitable
• application(s): clinical testing
• format: single component solution
• storage temp.: −20°C
• SMILES string: [2H]C([2H])([2H])NCCC=C1C2=C(C=CC=C2)CCC3=C1C=CC=C3.[H]Cl
• InChI: 1S/C19H21N.ClH/c1-20-14-6-11-19-17-9-4-2-7-15(17)12-13-16-8-3-5-10-18(16)19;/h2-5,7-11,20H,6,12-14H2,1H3;1H/i1D3;
• InChI key: SHAYBENGXDALFF-NIIDSAIPSA-N

Description

General description

Nortriptyline is a second generation tricyclic antidepressant (TCA) marketed under trade names such as Sensoval, Aventyl^®, and Pamelor^® for treatment of major depression. Nortriptyline is also an active metabolite of the TCA amitriptyline. This certified Snap-N-Spike^® Solution is suitable as an internal standard for quantitation of nortriptyline by LC/MS or GC/MS in clinical toxicology, forensic analysis, urine drug testing, isotope dilution methods, or medication monitoring applications.

Application

• Mass spectrometry standard: Nortriptyline-D3 hydrochloride solution is utilized as a high-precision internal standard in mass spectrometry to quantify nortriptyline levels in biological samples, essential for clinical pharmacokinetic studies and therapeutic drug monitoring.
• Metabolite research: As a stable isotope-labeled nortriptyline, it aids in metabolite profiling, helping researchers identify and quantify nortriptyline metabolites in various matrices, which is crucial for understanding drug metabolism and disposition.
• Pharmacokinetic studies: The solution is applied in pharmacokinetic research to assess the absorption, distribution, metabolism, and excretion (ADME) of nortriptyline, providing insights into the drug′s efficacy and safety profiles.
• Quantitative analysis: In bioanalytical research, Nortriptyline-D3 hydrochloride serves as a standard in developing and validating analytical methods, ensuring accuracy and reproducibility in the quantification of nortriptyline in pharmaceutical formulations and clinical samples.

Legal Information

Aventyl is a registered trademark of Eli Lilly and Co.

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany

Pamelor is a registered trademark of Mallinckrodt Inc.

Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• pictograms: GHS02,GHS06,GHS08
• signalword: Danger
• hcodes: H225,H301 + H311 + H331,H370
• pcodes: P210 - P280 - P301 + P310 + P330 - P302 + P352 + P312 - P304 + P340 + P311
• Hazard Classifications: Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1
• target_organs: Eyes
• Storage Class: 3 - Flammable liquids
• wgk_germany: WGK 1
• flash_point_f: 49.5 °F
• flash_point_c: 9.7 °C