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C-006

Supelco

Codeine solution

1 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

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About This Item

Empirical Formula (Hill Notation):
C18H21NO3
CAS Number:
76-57-3
Molecular Weight:
299.36
EC Number:
200-659-6
UNSPSC Code:
41116107
NACRES:
NA.24

grade

certified reference material

form

liquid

feature

SNAP-N-SPIKE®, SNAP-N-SHOOT®

packaging

ampule of 1 mL

manufacturer/tradename

Cerilliant®

drug control

Narcotic Licence Schedule A (Switzerland); estupefaciente (Spain); Decreto Lei 15/93: Tabela IA (Portugal)

concentration

1 mg/mL in methanol

technique(s)

gas chromatography (GC): suitable
liquid chromatography (LC): suitable

application(s)

forensics and toxicology

format

single component solution

storage temp.

−20°C

SMILES string

COc1ccc2C[C@@H]3[C@@H]4C=C[C@H](O)[C@@H]5Oc1c2[C@]45CCN3C

InChI

1S/C18H21NO3/c1-19-8-7-18-11-4-5-13(20)17(18)22-16-14(21-2)6-3-10(15(16)18)9-12(11)19/h3-6,11-13,17,20H,7-9H2,1-2H3/t11-,12+,13-,17-,18-/m0/s1

InChI key

OROGSEYTTFOCAN-DNJOTXNNSA-N

Gene Information

human ... OPRD1(4985) , OPRK1(4986) , OPRM1(4988)

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General description

Codeine is an opiate used for its analgesic, antitussive, and sedative properties and is the second-most predominant alkaloid in opium. This certified reference solution is suitable for use as a starting material in calibrators and controls for LC/MS and GC/MS testing methods in clinical toxicology, forensic analysis, pharmaceutical research, and pain prescription monitoring. As a widely popular recreational drug, codeine is regulated under various narcotic control laws in countries such as Australia, New Zealand, Romania, Sweden, and the United States. Since opiates are classified as controlled substances, Cerilliant offers most opiate reference standards as DEA-exempt solutions for added convenience.

Application


  • Codeine Solution in Opioid Receptor Studies: A recent review discusses the phytochemical and nutritional composition of Papaver plants, known for containing codeine. It outlines the plant′s biotechnological applications, potentially relevant for opioid receptor studies, and can be a basis for developing high-purity codeine solutions for research purposes. This highlights codeine′s role in biochemical research, especially in studying analgesic mechanisms and opioid receptor pharmacology (Butnariu et al., 2022).

Legal Information

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

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D-019

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D-087

Dihydrocodeine-D6 hydrochloride solution, 1.0 mg/mL in methanol (as free base), ampule of 1 mL, certified reference material, Cerilliant®

N-005

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C-006S

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signalword

Danger

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1

target_organs

Eyes,Central nervous system

Storage Class

3 - Flammable liquids

wgk_germany

WGK 2

flash_point_f

51.8 °F - closed cup

flash_point_c

11.0 °C - closed cup

Certificates of Analysis (COA)

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Mladen V Tzvetkov et al.
Biochemical pharmacology, 86(5), 666-678 (2013-07-10)
We investigated whether morphine and its pro-drug codeine are substrates of the highly genetically polymorphic organic cation transporter OCT1 and whether OCT1 polymorphisms may affect morphine and codeine pharmacokinetics in humans. Morphine showed low transporter-independent membrane permeability (0.5 × 10⁻⁶
K Krause et al.
Allergy, 68(2), 256-258 (2013-01-17)
Platelet-activating factor (PAF) causes wheal and flare responses which are abrogated by H1-antihistamines giving rise to the hypothesis that PAF-induced wheal development is secondary to histamine release from dermal mast cells. But is this hypothesis correct? Wheal and flare responses
Is it farewell to codeine?
Brian J Anderson
Archives of disease in childhood, 98(12), 986-988 (2013-08-27)
Rajeev Subramanyam et al.
International journal of pediatric otorhinolaryngology, 77(2), 194-199 (2012-11-20)
Although commonly performed, pediatric tonsillectomy is not necessarily a low risk procedure due to potentially life threatening perioperative complications. There is paucity of literature on lethal anesthesia and surgical complications of tonsillectomy. In this article, we have reviewed both minor
Laurence Toms et al.
The Cochrane database of systematic reviews, (1)(1), CD001547-CD001547 (2009-01-23)
This is an updated version of the Cochrane review published in Issue 4, 1998. Combining drugs from different classes with different modes of action may offer opportunity to optimise efficacy and tolerability, using lower doses of each drug to achieve
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