Skip to Content
MilliporeSigma
All Photos(1)

Documents

LM1600

Avanti

13:0 Lyso LPC

Avanti Research™ - A Croda Brand

Synonym(s):

1-tridecanoyl-sn-glycero-3-phosphocholine

Sign Into View Organizational & Contract Pricing
All Photos(1)

About This Item

Empirical Formula (Hill Notation):
C21H44NO7P
CAS Number:
20559-17-5
Molecular Weight:
453.55
UNSPSC Code:
12352211
NACRES:
NA.25

form

methanol solution

packaging

pkg of 1 × 1 mL (LM1600-1EA)

manufacturer/tradename

Avanti Research™ - A Croda Brand

concentration

~10 μg/mL (Refer to C of A for lot specific concentration. )

application(s)

lipidomics
metabolomics

shipped in

dry ice

storage temp.

−20°C

SMILES string

O[C@](COP(O)(OCC[N+](C)(C)C)=O)([H])COC(CCCCCCCCCCCC)=O

General description

Lysophosphatidylcholine (LPC) is a polar lipid, localized to the cell membranes of oxidized lipoproteins.

Application

13:0 Lyso LPC or 1-tridecanoyl-sn-glycero-3-phosphocholine has been used as an internal standard in:
  • lipid extraction from brain tissues
  • lipid extraction from macrophages using modified Bligh and Dyer protocol
  • liquid chromatography/MS analyses of lysophospholipids

Biochem/physiol Actions

Lysophosphatidylcholine (LPC) is known to be a bioactive molecule, associated with the progression of atherosclerosis, with findings of high concentration of LPC in the lesions/plaques. Higher levels of LPC are also found in oxidatively damaged low-density lipoprotein (oxLDL) indicating cardiovascular disease. LPC is involved in various biological processes such as vascular reproduction, development and myelination. It is also known to be implicated in neuronal diseases and cancer.

Packaging

2 mL Amber Glass Sealed Ampule (LM1600-1EA)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

signalword

Danger

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1

target_organs

Eyes

Storage Class

3 - Flammable liquids

wgk_germany

WGK 2

flash_point_f

49.5 °F - closed cup

flash_point_c

9.7 °C - closed cup

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Kasey C Vickers et al.
Atherosclerosis, 211(1), 122-129 (2010-05-11)
Calcifying vascular cells in human atherosclerotic plaques actively contribute to ectopic vascular mineralization. Lyso-phosphatidylcholine (LPC), a product of oxidized phosphatidylcholine hydrolysis, is found at concentrations of 1-12 microg/g tissue throughout the atheroma. The objective of this study was to determine
Jaewoo Choi et al.
Chemical research in toxicology, 24(1), 111-118 (2010-10-27)
Elevated levels of lysophosphatidylcholine (lysoPC), present in oxidatively damaged low-density lipoprotein (oxLDL), are implicated in cardiovascular complications. LysoPC is generated by free radical-catalyzed oxidation of polyunsaturated PCs to oxidatively truncated phosphophatidylcholines (oxPCs). It is known that oxPCs are especially susceptible
Shayne A Snider et al.
The Journal of biological chemistry, 293(29), 11600-11611 (2018-06-09)
Choline is an essential nutrient that is required for synthesis of the main eukaryote phospholipid, phosphatidylcholine. Macrophages are innate immune cells that survey and respond to danger and damage signals. Although it is well-known that energy metabolism can dictate macrophage
Matthew W Granger et al.
Journal of neurochemistry, 149(4), 499-517 (2018-07-25)
Changes in glycerophosphocholine metabolism are observed in Alzheimer's disease; however, it is not known whether these metabolic disruptions are linked to cognitive decline. Here, using unbiased lipidomic approaches and direct biochemical assessments, we profiled Land's cycle lipid remodeling in the
Judith Simcox et al.
Cell metabolism, 26(3), 509-522 (2017-09-07)
Cold-induced thermogenesis is an energy-demanding process that protects endotherms against a reduction in ambient temperature. Using non-targeted liquid chromatography-mass spectrometry-based lipidomics, we identified elevated levels of plasma acylcarnitines in response to the cold. We found that the liver undergoes a
View All Related Papers

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service