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900408P

Avanti

pacFA-18:1 PC

Avanti Research™ - A Croda Brand 900408P, powder

Synonym(s):

1-(9-(3-pent-4-ynyl-3-H-diazirin-3-yl)-nonanoyl)-2-oleoyl-sn-glycero-3-phosphocholine

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About This Item

Empirical Formula (Hill Notation):
C41H74N3O8P
CAS Number:
2260670-75-3
Molecular Weight:
768.02
UNSPSC Code:
12352211
NACRES:
NA.25

assay

>99% (TLC)

form

powder

packaging

pkg of 1x10 mg (900408P-10MG)
pkg of 1 × 1 mg (with stopper and crimp cap (900408P-1mg))
pkg of 1 × 5 mg (with stopper and crimp cap (900408P-5mg))

manufacturer/tradename

Avanti Research™ - A Croda Brand 900408P

lipid type

click reagents
phospholipids

shipped in

dry ice

storage temp.

−20°C

SMILES string

C#CCCCC1(N=N1)CCCCCCCCC(OC[C@@]([H])(OC(CCCCCCC/C=C\CCCCCCCC)=O)COP([O-])(OCC[N+](C)(C)C)=O)=O

InChI key

MZZDOXWHMLEPLR-FZMBPTIQSA-N

General description

The pacFA lipid attached to 2-oleoyl-sn-glycero-3-phosphocholine, contains a photoactivable diazirine ring with a clickable alkyne group.

Biochem/physiol Actions

1-(9-(3-pent-4-ynyl-3-H-diazirin-3-yl)-nonanoyl)-2-oleoyl-sn-glycero-3-phosphocholine (pacFA-18:1 PC) may be used for global analysis of protein–lipid interactions in living cells. pacFA acts as a precursor for the biosynthesis of bifunctional lipids. Proteins in contact with the bifunctional lipids are then cross-linked by ultraviolet (UV) irradiation of the diazirine ring. Finally, click chemistry is used to label the alkyne with a reporter molecule.

Packaging

2 mL Amber Serum Vial with Stopper and Crimp Cap (900408P-1mg)
2 mL Amber Serum Vial with Stopper and Crimp Cap (900408P-5mg)
5 mL Amber Glass Screw Cap Vial (900408P-10MG)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Storage Class

11 - Combustible Solids

flash_point_f

No data available

flash_point_c

No data available

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Mathias J Gerl et al.
PloS one, 11(4), e0153009-e0153009 (2016-04-23)
Cell membranes contain hundreds to thousands of individual lipid species that are of structural importance but also specifically interact with proteins. Due to their highly controlled synthesis and role in signaling events sphingolipids are an intensely studied class of lipids.
Per Haberkant et al.
Biochimica et biophysica acta, 1841(8), 1022-1030 (2014-01-21)
Understanding biological processes at the mechanistic level requires a systematic charting of the physical and functional links between all cellular components. While protein-protein and protein-nucleic acid networks have been subject to many global surveys, other critical cellular components such as
In vivo profiling and visualization of cellular protein-lipid interactions using bifunctional fatty acids.
Per Haberkant et al.
Angewandte Chemie (International ed. in English), 52(14), 4033-4038 (2013-03-02)

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