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890704P

Avanti

18:1 EPC (Cl Salt)

Avanti Research™ - A Croda Brand

Synonym(s):

1,2-dioleoyl-sn-glycero-3-ethylphosphocholine (chloride salt)

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About This Item

Empirical Formula (Hill Notation):
C46H89NO8PCl
CAS Number:
474945-24-9
Molecular Weight:
850.63
MDL number:
MFCD22495359
UNSPSC Code:
12352211
NACRES:
NA.25

form

powder

packaging

pkg of 1 × 100 mg (890704P-100mg)
pkg of 2 × 100 mg (890704P-200mg)
pkg of 1 × 25 mg (890704P-25mg)

manufacturer/tradename

Avanti Research™ - A Croda Brand

lipid type

cationic lipids
transfection

shipped in

dry ice

storage temp.

−20°C

SMILES string

O=P(OCC[N+](C)(C)C)(OC[C@]([H])(OC(CCCCCCC/C=C\CCCCCCCC)=O)COC(CCCCCCC/C=C\CCCCCCCC)=O)OCC.[Cl-]

InChI

1S/C46H89NO8P.ClH/c1-7-10-12-14-16-18-20-22-24-26-28-30-32-34-36-38-45(48)51-42-44(43-54-56(50,52-9-3)53-41-40-47(4,5)6)55-46(49)39-37-35-33-31-29-27-25-23-21-19-17-15-13-11-8-2;/h22-25,44H,7-21,26-43H2,1-6H3;1H/q+1;/p-1/b24-22-,25-23-;/t44-,56?;/m1./s1

InChI key

LXTQBOAODSPEHG-NATHRRJOSA-M

General description

18:1 EPC (Cl Salt) is a cationic lipid.[1]

Application

18:1 EPC (Cl Salt) is suitable:
  • for the preparation of lipid-nanoparticles[2]
  • for the use with 90% of 1,2-dioleoyl-sn-glycero-3-ethylphosphocholine (DOPC) to produce doped giant unilamellar vesicles[3]
  • as an emulsifier to study it′s in vitro transfection activity with respect to cationic lipid changes[4]

Packaging

5 mL Clear Glass Sealed Ampule (890704P-100mg)
5 mL Clear Glass Sealed Ampule (890704P-200mg)
5 mL Clear Glass Sealed Ampule (890704P-25mg)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Storage Class

11 - Combustible Solids

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Optimization of lipid composition in cationic emulsion as in vitro and in vivo transfection agents
Kim TW, et al.
Pharmaceutical Research, 18(1), 54-60 (2001)
Enhanced intrapulmonary delivery of anticancer siRNA for lung cancer therapy using cationic ethylphosphocholine-based nanolipoplexes
Shim G, et al.
Molecular Therapy, 21(4), 816-824 (2013)
Controlling loading and optical properties of gold nanoparticles on liposome membranes
Sau TK, et al.
Colloids and Surfaces. A, Physicochemical and Engineering Aspects, 342(1-3), 92-96 (2009)
Lipid nanoparticles for delivery of messenger RNA to the back of the eye
Patel S, et al.
J. Controlled Release, 303, 91-100 (2019)
Kabir H Biswas et al.
Langmuir : the ACS journal of surfaces and colloids, 34(4), 1775-1782 (2017-12-28)
The pathway of vesicle adsorption onto a solid support depends on the material composition of the underlying support, and there is significant interest in developing material-independent strategies to modulate the spectrum of vesicle-substrate interactions on a particular surface. Herein, using
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